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anti-Human IGF1 Antikörper:
anti-Mouse (Murine) IGF1 Antikörper:
anti-Rat (Rattus) IGF1 Antikörper:
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Human Polyclonal IGF1 Primary Antibody für IF (p), IHC (p) - ABIN723605
Baykara, Aksu, Buyuk, Kiray, Sisman, Baykara, Dayi, Tas, Ozdemir, Arda, Uysal et al.: Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amygdala, hippocampus neuron density; and reduced serum ... in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2013
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Human Polyclonal IGF1 Primary Antibody für IHC (p), WB - ABIN3044390
Li, Zhang, Li, Zhao, Zhai, Yang, Kong, Wu, Chen, Teng: miR-18a counteracts AKT and ERK activation to inhibit the proliferation of pancreatic progenitor cells. in Scientific reports 2017
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Mouse (Murine) Polyclonal IGF1 Primary Antibody für WB - ABIN4321494
Go, Srivastava, Hernandez-Ono, Gang, Smith, Booth, Ginsberg, Mani: The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. in Cell metabolism 2014
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Human Polyclonal IGF1 Primary Antibody für IHC (p), WB - ABIN966342
Jansen, van Schaik, Ricker, Bullock, Woods, Gabbay, Nussbaum, Sussenbach, Van den Brande: Sequence of cDNA encoding human insulin-like growth factor I precursor. in Nature 1984
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Human Polyclonal IGF1 Primary Antibody für ELISA, IHC - ABIN1586056
Malempati, Weigel, Ingle, Ahern, Carroll, Roberts, Reid, Schmechel, Voss, Cho, Chen, Krailo, Adamson, Blaney: Phase I/II trial and pharmacokinetic study of cixutumumab in pediatric patients with refractory solid tumors and Ewing sarcoma: a report from the Children's Oncology Group. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012
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Human Polyclonal IGF1 Primary Antibody für ICC, IF - ABIN4321496
Lin, Jan, Kuo: Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. in Molecular pharmaceutics 2015
Human Polyclonal IGF1 Primary Antibody für ELISA, WB - ABIN4321495
Furundzija, Fritzsche, Kaufmann, Meyborg, Fleck, Kappert, Stawowy: IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling. in Biochemical and biophysical research communications 2010
Human Polyclonal IGF1 Primary Antibody für ELISA, WB - ABIN2474319
Singer, Mogg, Koestler, Pacher, Marton, Kubista, Schreiber: Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Human Polyclonal IGF1 Primary Antibody für ELISA, WB - ABIN561442
Herrero-Martín, Osuna, Ordóñez, Sevillano, Martins, Mackintosh, Campos, Madoz-Gúrpide, Otero-Motta, Caballero, Amaral, Wai, Braun, Eisenacher, Schaefer, Poremba, de Alava: Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target. in British journal of cancer 2009
Human Monoclonal IGF1 Primary Antibody für IHC (fro), IHC (p) - ABIN2474317
Hajduk, Ma?ecka, Derentowicz, Roszkowski: [Interstitial lung diseases. I. Pathomorphological and immunological aspects and the methods of studies]. in Pneumonologia polska 1990
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A large sequence divergence of the C-terminal domain (C-Ala) reshaped C-Ala in a way that changed the global architecture of alanyl-tRNA synthetase (AlaRS). This reshaping removed the role of C-Ala in prokaryotes for docking tRNA and instead repurposed it to form a dimer interface presenting a DNA-binding groove.
the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer (Review)
Circulating Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 (zeige IGFBP3 Antikörper) predict Three-months Outcome after Ischemic Stroke.
These findings reveal that IGFBP3 (zeige IGFBP3 Antikörper) is effective in lung cancer cells with high IGF1 signaling activity and imply that relevant biomarkers are essential in selecting lung cancer patients for IGF1-targeted therapy
These data support the hypothesis that down regulation of the insulin (zeige INS Antikörper)-like growth factor (IGF-I) signaling links decidual phosphorylated insulin (zeige INS Antikörper)-like growth factor-binding protein (IGFBP-1 (zeige IGFBPI Antikörper)) hyperphosphorylation to restricted fetal growth in placental insufficiency.
These data implicate insulin (zeige INS Antikörper) resistance as a potential suppressor of IGF-I-dependent cortical bone development.
Study found that exercise increased hippocampal IGF-I levels only in cycling females through estrogen stimulation. These results suggest that sex-specific brain IGF-I responses to physiological stimuli such as exercise contribute to dimorphic mood homeostasis that may explain sex differences in affective disorders.
The results show that IGF1 levels were lower in NAFLD (zeige TSC2 Antikörper) patients and suggest that the growth hormone (zeige GH1 Antikörper)-IFG1 system may be involved in the pathogenesis of NAFLD (zeige TSC2 Antikörper).
In type 2 diabetic patients insulin (zeige INS Antikörper) glargine depressed the serum IGF1 levels much more when compared to insulin (zeige INS Antikörper) detemir.
High IGF-1 serum levels are associated with breast cancer.
RIP3 (zeige MPRIP Antikörper) and phosphorylated MLKL expressions were relatively decreased in the IGF-1 receptor monoclonal antibody group compared to the non-treated group. IGF-1 may be associated with RIP3 (zeige MPRIP Antikörper)-mediated necroptosis in vitro, while blocking of the IGF-1 pathway may reduce LPS (zeige TLR4 Antikörper)-induced lung injuries in vivo.
The down-regulation of IGF-I signaling, as observed in old mice, leads to increasing the activity of FoxO (zeige FOXO3 Antikörper) factors that may be important for the neuroprotective effects seen with dietary restriction.
Data suggest that gut (zeige GUSB Antikörper) resident bacteria-derived short-chain fatty acids mediate microbiota induced changes in host IGF-1 levels and contribute to the effects of colonization on bone turnover.
High IGF1 expression is sensitive to initial injury intensity induced by freeze damage.
study revealed that only BMP-6 (zeige BMP6 Antikörper) was able to induce bone formation at the used dose and that the addition of IGF-1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 (zeige BMP6 Antikörper) with IGF-1 might be a better alternative than BMP-2 (zeige BMP2 Antikörper) for orthopedic surgery or bone tissue engineering approaches.
IGF-1 signaling in involved in the epithelial-mesenchymal transformation of B16-F10 (zeige F10 Antikörper) cells and in the control of the stem cell phenotype.
Findings provided morphological evidence that T-type Cav3.2 (zeige CACNA1H Antikörper) channel, at least partially, mediates the pain facilitation of insulin-like growth factor-1/insulin-like growth factor-1 receptor (zeige IGF1R Antikörper) signaling in chronic inflammatory pain condition.
Conditional deletion of IGF-1 in osteocytes enhanced bony union of the fracture gap in a tibial fracture model.
IGF-I stimulated IRS-1 (zeige IRS1 Antikörper) phosphorylation and recruitment of PKCzeta (zeige PRKCZ Antikörper) and vimentin (zeige VIM Antikörper) to phospho-IRS-1 (zeige IRS1 Antikörper).
local IGF-I plays critical roles during postnatal/adult hippocampal neurogenesis.
the dipeptide Pro-Asp (zeige ASIP Antikörper) promoted IGF-1 secretion and expression in hepatocytes.
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR (zeige FRAP1 Antikörper) and PPARg (zeige PPARG Antikörper). In summary, PPARg (zeige PPARG Antikörper) plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.
Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.
This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.
Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF (zeige HGF Antikörper) enhances neovascularization but moderately improves cardiac regeneration in a porcine model.
Results show that expression changes of IGF1 genes were associated with C/EBP (zeige CEBPA Antikörper) b expression during embryonic and postnatal development in porcine liver.
genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.
IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.
IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.
alpha-linolenic acid increased IGF-I secretion from hepatocytes.
Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin (zeige LEP Antikörper) on cell proliferation/apoptosis, MAP kinase (zeige MAPK1 Antikörper) signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin (zeige LEP Antikörper). (IGF1 = insulin-like growth factor I)
Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.
Our studies demonstrate that the active SVCT2 (zeige SLC23A2 Antikörper) is expressed in IVD (zeige IVD Antikörper) cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.
increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (zeige INS Antikörper) and IGF.
IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors
Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.
Findings show similar regulatory growth hormone (GH (zeige GH1 Antikörper)) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (zeige INS Antikörper)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha (zeige TNF Antikörper).
Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.
Study demonstrated that IGF-I can stimulate egfr (zeige EGFR Antikörper) expression in both follicles cell culture and intact follicles promoting oocyte maturation.
IGF-I-induced kitlga expression is inhibited by epidermal growth factor (zeige EGF Antikörper), an oocyte-derived paracrine factor in the zebrafish follicle.
hypoxia causes PGC (zeige PGC Antikörper) migration defect by inhibiting IGF signaling through the induction of IGFBP-1 (zeige IGFBPI Antikörper)
Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt (zeige AKT1 Antikörper) signaling activities, re-oxygenation restored their activities
IGF signalling influences expression of BMP2b (zeige BMP4 Antikörper), a gene that plays an important role in zebrafish pattern formation
The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts
zebrafish XBP-1 (zeige XBP1 Antikörper) spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt (zeige AKT1 Antikörper) pathway in unfolded protein
IGF1/RsaI was associated with average daily weight gain in cattle.
Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.
IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.
There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 (zeige STAT5A Antikörper) ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.
Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.
The association of IGF1, GH, and PIT1 (zeige POU1F1 Antikörper) markers with growth and reproductive traits were assessed.
These findings strongly support the concept that IGF-1 upregulates LHR (zeige LHCGR Antikörper) expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.
Insulin (zeige INS Antikörper)-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase (zeige MAPK1 Antikörper)-mediated signaling pathways.
Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (zeige IGFBP3 Antikörper)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
The laminar cell types expressing insulin receptor (zeige INSR Antikörper) and/or insulin-like growth factor-1 receptor (zeige IGF1R Antikörper) and the effect of dietary carbohydrates on their expression are reported.
Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.
Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor (zeige IGF1R Antikörper) is present in spermatogonia, spermatocytes and Leydig cells.
Hsp90 (zeige HSP90AB1 Antikörper) inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.
Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.
Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.
These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.
Relative levels of IGF-I and MSTN (zeige MSTN Antikörper) mRNA may participate in ordering duck muscle growth rates with selected development.
Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.
, alanine tRNA ligase 1, cytoplasmic
, alanine--tRNA ligase, cytoplasmic
, alanyl-tRNA synthetase, cytoplasmic
, renal carcinoma antigen NY-REN-42
, insulin-like growth factor 1
, insulin-like growth factor I
, insulin-like growth factor IA
, insulin-like growth factor IB
, mechano growth factor
, somatomedin C
, insulin-like growth factor-1
, Insulin-like growth factor I
, class 1 insulin-like growth factor I preproprotein
, insulin growth factor-1
, insulin like growth factor 1
, insulin-like growth factor I (somatomedin C)
, insulin-like growth factor I variant 1
, insulin like growth factor-1
, insulin-like growth factor-I
, insulin-like growth factor 1 (somatomedin C)
, insulin like growth factor 1 S homeolog
, insulin-like growth factor I-A