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anti-Human FLT1 Antikörper:
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Mouse (Murine) Polyclonal FLT1 Primary Antibody für BR, ELISA (Capture) - ABIN5013029
Matsuno, Kozawa, Yoshimi, Akamatsu, Hara, Mori, Okada, Ueshima, Matsuo, Uematsu: Lack of alpha2-antiplasmin promotes pulmonary heart failure via overrelease of VEGF after acute myocardial infarction. in Blood 2002
Show all 25 Pubmed References
Human Polyclonal FLT1 Primary Antibody für BR, CyTOF - ABIN5013028
Giuliani, Colla, Lazzaretti, Sala, Roti, Mancini, Bonomini, Lunghi, Hojden, Genestreti, Svaldi, Coser, Fattori, Sammarelli, Gazzola, Bataille, Almici, Caramatti, Mangoni, Rizzoli: Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis. in Blood 2003
Show all 23 Pubmed References
Human Monoclonal FLT1 Primary Antibody für FACS - ABIN4897100
Karrar, Broomé, Uzunel, Qureshi, Sumitran-Holgersson: Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. in Gut 2007
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Human Monoclonal FLT1 Primary Antibody für CyTOF, FACS - ABIN4900044
Brave, Eberlein, Shibuya, Wedge, Barry: Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model. in Angiogenesis 2010
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Human Monoclonal FLT1 Primary Antibody für FACS - ABIN4897099
de Groot, Piao, Tran, Gilbert, Wu, Liu, Bekele, Cloughesy, Mehta, Robins, Lassman, DeAngelis, Camphausen, Chen, Yung, Prados, Wen, Heymach: Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
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Mouse (Murine) Monoclonal FLT1 Primary Antibody für FACS - ABIN4897107
Reddy, Zhou, Schadler, Jia, Kleinerman: Bone marrow subsets differentiate into endothelial cells and pericytes contributing to Ewing's tumor vessels. in Molecular cancer research : MCR 2008
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Human Polyclonal FLT1 Primary Antibody für ICC, IF - ABIN151960
Rahimi, Dayanir, Lashkari: Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. in The Journal of biological chemistry 2000
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Mouse (Murine) Monoclonal FLT1 Primary Antibody für FACS - ABIN4897104
Weston, Zayas, Perez, George, Jurecic: Dynamic equilibrium of heterogeneous and interconvertible multipotent hematopoietic cell subsets. in Scientific reports 2014
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Human Polyclonal FLT1 Primary Antibody für IF (p), IHC (p) - ABIN725795
Cheng, Xiang, Yang, Ma, Zhao: Direct Effects of Bevacizumab on Rat Conjunctival Fibroblast. in Cell biochemistry and biophysics 2015
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Human Polyclonal FLT1 Primary Antibody für WB - ABIN2801854
Kendall, Thomas: Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. in Proceedings of the National Academy of Sciences of the United States of America 1993
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Our study suggests that "migration" of the placenta is derived from placental degeneration at the caudal (zeige CAD Antikörper) part of the placenta, and sFlt-1 plays a role in this placental degeneration.
the association of VEGFR1 rs9582036 and rs9554320 with the outcome of sunitinib in mRCC patients did not reach the threshold for statistical significance, and therefore, both genetic variants have limited use as biomarkers for prediction of sunitinib efficacy.
By comparing in vivo data with immunohistochemical analysis of excised tumors we found an inverse correlation between 99mTc-VEGF165 uptake and VEGF (zeige VEGFA Antikörper) histologically detected, but a positive correlation with VEGF receptor expression (VEGFR1).
Icrucumab and ramucirumab are recombinant human IgG1 monoclonal antibodies that bind vascular endothelial growth factor (VEGF (zeige VEGF Antikörper)) receptors 1 and 2 (VEGFR-1 and -2), respectively. VEGFR-1 activation on endothelial and tumor cell surfaces increases tumor vascularization and growth and supports tumor growth via multiple mechanisms, including contributions to angiogenesis and direct promotion of cancer cell proliferation.
Cases with high MDSC infiltration, which was inversely correlated with intratumoral CD8 (zeige CD8A Antikörper)(+) T-cell infiltration, exhibited shorter overall survival. In a mouse model, intratumoral MDSCs expressed both VEGFR1 and VEGFR2 (zeige KDR Antikörper). VEGF (zeige VEGFA Antikörper) expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis
Circulating tissue transglutaminase is associated with sFlt-1, soluble endoglin and VEGF in the maternal circulation of preeclampsia patients, suggesting that tTG may have a role in the pathogenesis of PE.
The authors observed direct damage caused by sFLT1 in tumour cells. They exposed several kinds of cells derived from ovarian and colorectal cancers as well as HEK293T cells to sFLT1 in two ways, transfection and exogenous application. The cell morphology and an lactate dehydrogenase assay revealed cytotoxicity.
Altered antiangiogenic state because of altered circulating sFlt1 leads to Preeclampsia, ratio of sFlt1/PlGF (zeige PGF Antikörper) correlates with Preeclampsia phenotypes.
Gestation-adjusted sEng, sFlt-1 and PlGF (zeige PGF Antikörper) levels were 11%, 36%, and 30%, respectively, lower in women who later suffered miscarriage compared with unaffected pregnancies
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (zeige IL6 Antikörper) (40.2pg/mL), VEGF-A (zeige VEGFA Antikörper) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (zeige PRAP1 Antikörper) (248.1pg/mL), sHER-2/neu (zeige ERBB2 Antikörper) (5010pg/mL) and PLGF (zeige PGF Antikörper) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
we determined that radial glia control this process via the Vegf (zeige VEGFA Antikörper) decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.
Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt (zeige AKT1 Antikörper) pathway.
Elevated Notch (zeige NOTCH1 Antikörper) signaling downstream of perturbed VEGF (zeige VEGFA Antikörper) signaling contributes to aberrant flt-1(-/-) blood vessel formation.
Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 (zeige LILRB2 Antikörper) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 (zeige KDR Antikörper) signaling.
This is the first report demonstrating the spatiotemporal expression patterns of Flk1 (zeige KDR Antikörper) and Flt1 in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis.
sFlt-1 overexpression in Padi4 (zeige PADI4 Antikörper)(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.
endothelial dysfunction due to high circulating sFLT1 may be the primary event leading to enhanced vasoconstrictor sensitivity that is characteristic of preeclampsia
Flt1 has a role in blood vessel anastomosis during angiogenesis
First-in-class selective PET tracers for imaging VEGFR-1 and VEGFR-2 (zeige KDR Antikörper) were constructed and successfully validated in an orthotopic murine tumor model.
these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in streptozotocin -induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis.
These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B (zeige VEGFB Antikörper) to VEGFR1.
Flt1/VEGF-A (zeige VEGFA Antikörper) signalling has stage-specific effects on vascular morphogenesis.
IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor (zeige VEGF Antikörper) and its receptors
There is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF (zeige VEGFA Antikörper) receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.
gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)
Alterations in the expression of VEGF-A (zeige VEGFA Antikörper) and bFGF (zeige FGF2 Antikörper) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.
TGF-beta1 (zeige TGFB1 Antikörper) induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen(VEGFR-1)
the activation of VEGFR-1 and VEGFR-2 (zeige KDR Antikörper) heterodimer (VEGFR-1/R-2) is essential for PGI(2 (zeige PTGIR Antikörper)) synthesis mediated by VEGF-A (zeige VEGFA Antikörper)(165) and VEGF-A (zeige VEGFA Antikörper)(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 (zeige KDR Antikörper) homodimers with corresponding agonists
PEDF (zeige SERPINF1 Antikörper) and VEGFR-1 have roles in the negative regulation of angiogenesis
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1) and Flk-1 (KDR/VEGFR-2 (zeige KDR Antikörper))in newborn piglet brain
data shows that members of the VEGF (zeige VEGFA Antikörper)-VEGFR (zeige KDR Antikörper) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
The VEGFR1 was stably expressed during the whole lifespan of mesonephric glomeruli, and VEGFR1 is important for the maintenance of endothelial fenestrations.
increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig.
EGFR (zeige EGFR Antikörper), VEGFR (zeige KDR Antikörper) and FGFR (zeige FGFR2 Antikörper) are expressed in porcine oviduct and endometrium during the time of implantation [review]
VEGF (zeige VEGFA Antikörper) ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (zeige VEGFA Antikörper)/Flk-1 (zeige KDR Antikörper)/Flt-1 system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Antikörper), pro-MMP-9 (zeige MMP9 Antikörper), MMP-2 (zeige MMP2 Antikörper), VEGFR-1, VEGFR-2 (zeige KDR Antikörper), and TIMP-1 (zeige TIMP1 Antikörper), which may contribute to the development of venous stenosis.
in experimental intervertebral disc degeneration, VEGF (zeige VEGFA Antikörper) receptors were expressed in the damaged disc and paradiscal tissues
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
fms-like tyrosine kinase 1
, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
, tyrosine-protein kinase FRT
, tyrosine-protein kinase receptor FLT
, vascular endothelial growth factor receptor 1
, vascular permeability factor receptor
, FMS-like tyrosine kinase 1
, Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
, vascular endothelial growth factor receptor-1
, fms-related tyrosine kinase 1
, receptor tyrosine kinase Flt1b
, soluble fms-like tyrosine kinase 1
, embryonic receptor kinase 2
, vascular endothelial growth factor/vascular permeability factor receptor
, ascular endothelial growth factor/vascular permeability factor receptor
, vascular endothelial growth factor 1
, flt-1 type VEGF receptor