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anti-Human Angiopoietin 1 Antikörper:
anti-Mouse (Murine) Angiopoietin 1 Antikörper:
anti-Rat (Rattus) Angiopoietin 1 Antikörper:
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Human Polyclonal Angiopoietin 1 Primary Antibody für IF (p), IHC (p) - ABIN728323
Lv, Fan, Su: Is a swine model of arteriovenous malformation suitable for human extracranial arteriovenous malformation? A preliminary study. in Cardiovascular and interventional radiology 2013
Show all 4 Pubmed References
Mouse (Murine) Polyclonal Angiopoietin 1 Primary Antibody für IHC, WB - ABIN95109
Dallabrida, Ismail, Pravda, Parodi, Dickie, Durand, Lai, Cassiola, Rogers, Rupnick: Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
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Human Polyclonal Angiopoietin 1 Primary Antibody für IHC (p), WB - ABIN965551
Suri, Jones, Patan, Bartunkova, Maisonpierre, Davis, Sato, Yancopoulos: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. in Cell 1997
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Human Polyclonal Angiopoietin 1 Primary Antibody für IHC, WB - ABIN6136873
Huang, Han, Sun, Zhao, Liu, Yuan, Mao, Peng, Liu, Yin, He: Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis. in Cell & bioscience 2017
Human Polyclonal Angiopoietin 1 Primary Antibody für IHC, IHC (p) - ABIN4280606
Zibert, Wallbrecht, Schön, Mir, Jacobsen, Trochon-Joseph, Bouquet, Villadsen, Cadossi, Skov, Schön: Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions. in The Journal of clinical investigation 2011
Chicken Monoclonal Angiopoietin 1 Primary Antibody für IHC (fro), IHC (p) - ABIN259879
Regula, Lundh von Leithner, Foxton, Barathi, Cheung, Bo Tun, Wey, Iwata, Dostalek, Moelleken, Stubenrauch, Nogoceke, Widmer, Strassburger, Koss, Klein, Shima, Hartmann: Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases. in EMBO molecular medicine 2016
Human Polyclonal Angiopoietin 1 Primary Antibody für ELISA, WB - ABIN6259926
Wu, Hu, Yin, Li, Zhang: [Dose and timing of normal saline resuscitation on endothelial glycocalyx in early septic shock]. in Zhonghua wei zhong bing ji jiu yi xue 2018
Human Polyclonal Angiopoietin 1 Primary Antibody für IHC (p), ELISA - ABIN3044373
Sun, Wang, Cheng, Wang, Li, Xue, Wang, Ai, Zhang, Xu, Wang, Ji: Morroniside improves microvascular functional integrity of the neurovascular unit after cerebral ischemia. in PLoS ONE 2014
ANGPT1 impairment is associated with angioedema, and ANGPT1 variants can be the basis of Hereditary angioedema.
Ang-2/Ang-1 ratio higher in children with septic shock
an increased level of keratinocyte growth factor (KGF) and angiopoietin1 (ANGPT1) secretion from mesenchymal stem cells was observed under inflammatory stimulation.
transcription of VEGF and ANG-1 was significantly higher at 2% oxygen than at 21% O2. The optimum oxygen range at which hMSCs proliferated rapidly and angiogenic factors ANG-1 and VEGF simultaneously came to expression was from 1 to 2% oxygen.
By linking ANGPT1 with Primary congenital glaucoma , these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.
ERG is an endothelial transcriptional effector activated downstream of Ang1 to promote Notch signalling and vascular stability. Ang1 is able to phosphorylate ERG via PI3K/Akt, and this promotes the formation of an ERG-beta catenin complex, which binds multiple sites in the Dll4 locus and drives Dll4 expression.
miR-876-5p suppressed proliferation by restraining the expression of Ang-1, which would regulate the phosphorylation level of PI3K, AKT, mTOR and ERK in psoriasic cells.
hyperoxia as well as increased TGFbeta signaling is a major contributor to the increased levels of miR34a, which mediate injury via angiopoietin-1 in neonatal lungs
High Angpt2 and low Angpt1 levels were positively associated with abnormal cardiac structure.
findings reveal a novel role for miR-204/ANGPT1/TGFbetaR2 axis in tumor angiogenesis. We propose that therapeutic manipulation of miR-204 levels may represent a promising approach in breast cancer.
VEGF plays a role in the induction of of ANGPT1 in skeletal muscle to stimulate angiogenesis.
no significant difference in liver expression between chronic hepatitis C patients and controls
serum Ang-2 and Ang-1 levels may help in the diagnosis of patients with lymphatic anomalies and are concordant to sirolimus response.
Studied role of change in ratio of angiopoietin-2 (Ang-2) to angiopoietin-1 (Ang-1) levels in hantavirus ionfections. Found imbalance in ang-2:ang-1 lasted through the acute infection phase.
Bicarbonate buffered PD fluid promotes vessel maturation via upregulation of angiopoietin-1 in vitro and in children on dialysis
When Tie2 becomes inactivated, important molecular brakes are released in the endothelium, which in turn potentiate inflammation and vascular leakage. The ligands of Tie2, Angiopoietin-1 and Angiopoietin-2, regulate its activation status.
These data suggest that certain DCE-MRI parameters correlate with R-ISS and adverse prognostic features of angiogenesis, such as the ratio of Angp-1/Angp-2.
study revealed decreased levels of VEGF, ANGPT1, and MMP-9 in the early post-transplant period as compared to the baseline (BC). ANGPT2 was decreased after conditioning treatment, but tended to increase from day +7. On day +7, positive correlations between ANGPT1 level as well as MMP-9 and the time to engraftment were observed.
These results indicate that the Angpt-Tie2 system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma.
Ang-1 specifically increases circulating Gr1(+ )inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis.
Our study provides evidence supporting that Ang-1-modified Bone marrow mesenchymal stem cells may have preventive and therapeutic effects on hyperoxia-induced optic nerve injury in neonatal mice.
Late gestational deletion of the angiopoietin receptor endothelial tyrosine kinase 2 (Tie2) or both angiopoietin-1 and angiopoietin-2 prevents ascending vasa recta formation in mice. The AVRs are Tie2 signaling-dependent specialized hybrid vessels.
the augmentation and downregulation of angiopoietin 1 attenuated renal damage and impaired renal recovery, respectively, by influencing the survival/regeneration of the endothelium. The manipulation of angiopoietin 1 represents a novel therapeutic approach for the treatment of ischemic kidney injury.
Data (including data from studies in transgenic mice) suggest that Dkk2 secreted from pericytes promotes angiogenesis and neurogenesis/neural regeneration via Angpt1/Tie2/Wnt signaling; here, overexpression of Dkk2 in diabetic mice enhances penile angiogenesis/neural regeneration and restores erectile function. (Dkk2 = dickkopf-2; Angpt1= angiopoietin-1; Tie2 = endothelial-specific receptor tyrosine kinase Tie2)
Angiopoietin-1/Tek vascular growth factor system leads to increased metastasis without affecting primary tumor growth.
Mesenchymal stem cell microvesicles attenuate acute lung injury in mice at least partially via angiopopietin-1 mRNA.
results suggest that loss of Angpt1 is central in capillary rarefaction and fibrogenesis and propose that manipulations to maintain Angpt1 levels may slow down fibrosis progression
These data define a role for dysregulation of the Ang-Tie-2 axis in the pathogenesis of cerebral malaria.
we demonstrate that targeted Ang-1 overexpression attenuates myofibroblast activation and interstitial collagen I accumulation, inhibits the upregulation of transforming growth factor beta1 and subsequent phosphorylation of Smad 2/3, dampens renal inflammation, and stimulates the growth of peritubular capillaries in the obstructed kidney.
Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoietin 1/ Tie-2 signaling pathway.
COMP-Ang1 can enhance BMP2-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.
Hematopoietic stem cells regulate the regeneration of their niche by secreting Angpt1.
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Ang-1 strongly enhances skeletal muscle regeneration in response to fiber injury and that this effect is mediated through induction of the myogenesis program in muscle progenitor cells and the angiogenesis program in endothelial cells.
These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang-Tie2 signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema
E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha, priming the middle cerebral artery territory for survival after experimental focal ischemia
The important role of Ang-1 in the activation of mast cells, and a potential therapeutic effect of Ang-1 on anaphylaxis diseases.
Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA.
Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
ANPT-1 becomes predominant in the follicle producing high levels of E(2), indicating the possible switch-over from ANPT-2 (antagonist) to ANPT-1 (agonist).
inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF-stimulated endothelial permeability by Ang-1.
Angiopoietin 1 was predominantly present in the maturing glomeruli.
The expression of ANGPT1 has already been studied during metanephric glomerulogenesis, but it remains to be elucidated during the development of the embryonic mesonephros.
Attenuates H2O2-induced stress-activated protein kinase (SEK)1/JNK phosphorylation through the PI 3-kinase/Akt pathway and inhibits the apoptosis of vascular endothelial cells induced by oxidative stress.
Estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks.
forward mandibular positioning enhance the expression of Ang1 and Ang2 in condylar cartilage.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, angiopoietin 1