PRPS1 Proteine (PRPS1)

Bezeichnung:: phosphoribosyl Pyrophosphate Synthetase 1 Proteine (PRPS1)

Auf www.antikoerper-online.de finden Sie aktuell 14 phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PRPS1 Antikörper (47) und PRPS1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 68 PRPS1 Produkte verfügbar.

Synonyme:: 2310010D17Rik, arts, C76571, C76678, cmtx5, DFN2, DFNX1, ppribp, Prps-1, prps1, PRS-I, prsi

alle Proteine anzeigen	Gen	GeneID	UniProt
	PRPS1	5631	P60891
	PRPS1	19139	Q9D7G0
	PRPS1	29562	P60892
Weitere Synonyme anzeigen

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Verknüpfte Pathways mit PRPS1 Proteine

Ribonucleoside Biosynthetic Process

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Human phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Interaktionspartner

This report highlights the unexpected finding of retinal degeneration in females caused by missense variants in the X-linked gene PRPS1 and expands our understanding of the phenotypic outcome of specific variants.
ARTS binds directly to both XIAP (zeige XIAP Proteine) and Bcl-2 (zeige BCL2 Proteine). ARTS functions as a distinct Bcl-2 (zeige BCL2 Proteine) antagonist by binding and leading to its degradation.
A novel PRPS1 mutation related to early-onset progressive nonsyndromic hearing loss.
High PRPS1 expression is associated with chemoresistance in breast cancer.
evaluation of current literature on PRPS1-related syndromes and summaries of potential therapies [review]
analysis of intrafamilial phenotypic variation associated with a single PRPS1 mutation in syndromic or nonsyndromic hearing impairment
CRC (zeige CALR Proteine) cells that overexpressed miR124 or with knockdown of RPIA (zeige RPIA Proteine) or PRPS1 had reduced DNA synthesis and proliferation, whereas cells incubated with an inhibitor of miR124 had significantly increased DNA synthesis and proliferation and formed more colonies.
Study identified the critical region in the ARTS promoter and demonstrated that the Sp1 transcription factor (zeige SP1 Proteine) could regulate the activity of the ARTS promoter through multiple Sp1 (zeige PSG1 Proteine) binding sites.
Females with a missense mutation in PRPS1, exhibit neuropathy, hearing loss and retinopathy.
the de novo purine synthesis inhibitor lometrexol effectively abrogated PRPS1 mutant-driven drug resistance.

Mouse (Murine) phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) Interaktionspartner

PRPS1 knockdown prolonged survival time, reduced tumor volume and upregulated apoptosis in xenograft mouse model of glioma.
Only unedited pri-miR (zeige MLXIP Proteine)-376 RNAs were detected in the cochlea suggesting that the activity of PRPS1 in the inner ear may not be regulated through the editing of miR (zeige MLXIP Proteine)-376 cluster.
PRPS1 loss of function mutations cause a type of nonsyndromic X-linked sensorineural deafness, DFN2

PRPS1 Protein Überblick

Protein Überblick

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PRPS1

phosphoribosyl pyrophosphate synthetase 1 (PRPS1)
phosphoribosyl pyrophosphate synthetase 1 (Prps1)
phosphoribosyl pyrophosphate synthetase 1 L homeolog (prps1.L)

2310010D17Rik Protein
arts Protein
C76571 Protein
C76678 Protein
cmtx5 Protein
DFN2 Protein
DFNX1 Protein
ppribp Protein
Prps-1 Protein
prps1 Protein
PRS-I Protein
prsi Protein

Bezeichner auf Proteinebene für PRPS1

dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1) , deafness 2, perceptive, congenital , deafness, X-linked 2, perceptive, congenital , phosphoribosyl pyrophosphate synthase I , ribose-phosphate diphosphokinase 1 , ribose-phosphate pyrophosphokinase 1 , phosphoribosyl pyrophosphate synthetase I , PRS-I , phosphoribosyl pyrophosphate synthetase 1 L homeolog

GENE ID	SPEZIES
5631	Homo sapiens
19139	Mus musculus
29562	Rattus norvegicus
781227	Bos taurus
399237	Xenopus laevis

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