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Human Polyclonal MAT2B Primary Antibody für ELISA, WB - ABIN565388
Wang, Liu, Liu, Qian, Sun, Pan: Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma. in World journal of gastroenterology : WJG 2008
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Human Polyclonal MAT2B Primary Antibody für IHC, IHC (p) - ABIN4332822
Ramani, Yang, Kuhlenkamp, Tomasi, Tsukamoto, Mato, Lu: Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. in Hepatology (Baltimore, Md.) 2010
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Human Polyclonal MAT2B Primary Antibody für ELISA, WB - ABIN4332825
LeGros, Halim, Geller, Kotb: Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). in The Journal of biological chemistry 2000
Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity.
Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf (zeige RAF1 Antikörper)/MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper) pathway
resveratrol induces HuR (zeige ELAVL1 Antikörper), SIRT1 (zeige SIRT1 Antikörper), and MAT2B expression; the last may represent a compensatory response against apoptosis and growth inhibition.
MAT2B and GIT1 form a scaffold, which recruits and activates MEK (zeige MAP2K1 Antikörper) and ERK (zeige EPHB2 Antikörper) to promote growth and tumorigenesis.
The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR (zeige SDPR Antikörper)) core with specificity for the NADP/H cofactor, and harbors the SDR (zeige SDPR Antikörper) catalytic triad.
Coexpression of MAT2A (zeige MAT2A Antikörper) and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity.
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR (zeige ELAVL1 Antikörper) subcellular content to affect cell proliferation.
Lower expression of both MAT2A (zeige MAT2A Antikörper) and MAT2beta and interfere with leptin (zeige LEP Antikörper) signaling in liver cancer cells.
Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death.
a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B
MAT2B acted as a positive regulator through modifying S- adenosylmethionine levels as well as activating AKT (zeige AKT1 Antikörper)/ERK (zeige MAPK1 Antikörper) signaling pathway to promote porcine intramuscular adipocyte differentiation.
These data demonstrated an obesity-related expression variation of the MAT II beta subunit (zeige POLG Antikörper) in skeletal muscle and adipose tissue in pigs.
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms.
MAT II beta
, beta regulatory subunit of methionine adenosyltransferase
, dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, methionine adenosyltransferase 2 subunit beta
, putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
, putative protein product of Nbla02999
, short chain dehydrogenase/reductase family 23E, member 1
, methionine adenosyltransferase 2 beta subunit
, methionine adenosyltransferase II beta
, methionine adenosyltransferase 2beta
, methionine adenosyltransferase II, beta
, methionine adenosyltransferase 2 subunit beta-like