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Human Polyclonal ATP2C2 Primary Antibody für ELISA, WB - ABIN542597
Dode, Andersen, Vanoevelen, Raeymaekers, Missiaen, Vilsen, Wuytack: Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses. in The Journal of biological chemistry 2006
Show all 3 Pubmed References
In total, four independent SNPs within DYX1C1 and ATP2C2 were found to be associated with MMR stronger than expected from multiple testing. To explore potential pathomechanisms, we annotated these variants with functional data including tissue-specific expression analysis and eQTLs.
The Secretory Pathway Ca(2+) -ATPases SPCA1 and SPCA2 are strongly induced under osteogenic conditions that elicit microcalcifications. SPCA gene expression is significantly elevated in breast cancer subtypes that are associated with microcalcifications.
The extract was found to comprise mainly primary fatty acid amides (PFAAs) by NMR analysis. Individual PFAAs, especially oleamide and linoleamide, almost completely inhibited hSPCA2 activity with IC50 values of 7.5 muM and 3.8 muM, respectively.
we found that SPCA2-transfected cells display a higher number of cells entering S phase. Altogether, our results point at the important role of SPCA2 in regulation of cell cycle in cancer cells
Orai1-mediated Ca(2+)-influx and SPCA2-mediated Ca(2+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2+) into the secretory pathway, which might play a role in SPCA2-expressing secretory cells, such as mammary gland during lactation.
Supporting a more general neurocognition role of ATP2C2 is the previous association of ATP2C2 with attention deficit hyperactivity disorder, a condition commonly comorbid with dyslexia and language impairment.
Findings reveal a signaling pathway in which the Orai1-SPCA2 complex elicits constitutive store-independent Ca(2+) signaling that promotes tumorigenesis.
SPCA2 may have a more specialized role in mammalian cells, possibly in cellular detoxification of Mn2+ ions.
hSPCA2 has the ability to transport Ca(2+) and Mn(2+); both its transport and Ca(2+)- and Mn(2+)-dependent phosphoprotein intermediate formation functions are insensitive to thapsigargin inhibition
analysis of SPCA1 and SPCA2 isoenzymes by steady-state and transient kinetic analyses
ATP2C2 modulates phonological short-term memory in language impairment.
The goal of this study was to delineate the gene structure and regulation of a novel pancreas-specific isoform for Secretory Pathway Ca(2+) ATPase 2 (termed SPCA2C), which is encoded from the Atp2c2 gene.
SPCA2 and Orai1 function together to regulate store-independent calcium entry.
Atp2c2 transcription is regulated by MIST1
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity).
ATPase, Ca++ transporting, type 2C, member 2
, calcium-transporting ATPase type 2C member 2-like
, calcium-transporting ATPase 2C2
, secretory pathway Ca,Mn-ATPase
, ATPase 2C2
, calcium-transporting ATPase type 2C member 2
, secretory pathway Ca(2+)-ATPase 2
, secretory pathway calcium ATPase 2
, Secretory pathway Ca(2+)-ATPase 2
, secretory pathway Ca2+-ATPase
, putative secretory pathway Ca-ATPase SPCA2