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Data suggest that SNRPA1, SNRPD1, and PNN are key players in the regulation of pluripotency-specific spliceosome assembly and the acquisition and maintenance of pluripotency.
Data show that the elevation of cerebrospinal fluid anti-Sm antibodies through transudation from systemic circulation due to damaged blood-brain barrier (BBB) plays a critical role in the pathogenesis of acute confusional state (ACS).
The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly.
Overexpression of SNRPD1 is associated with highly aggressive breast cancers.
data suggest that the anti-Sm D response arises as a consequence of antigenic cross-reactivity by anti-EBNA-1 antibodies, supporting a possible association between EBV infection and SLE
SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus.
This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.
, small nuclear ribonucleoprotein D1 polypeptide 16kDa pseudogene
, small nuclear ribonucleoprotein Sm D1
, snRNP core protein D1
, small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
, sm-D autoantigen