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Human NPM1 Protein expressed in Wheat germ - ABIN1312882
Xu, Fang, Dhar, St Clair, Kasarskis, St Clair: The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. in The Journal of biological chemistry 2007
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Mutation in NPM1 gene is associated with Acute Myeloid Leukemia (zeige BCL11A Proteine).
Nucleoplasmic translocation of NPM1 is a prerequisite for stress-induced activation of p53 (zeige TP53 Proteine).
NPM1 gene B type mutation enhanced the proliferation and invasion of THP-1 AML (zeige RUNX1 Proteine) cells through the regulation of TIMP-2 (zeige TIMP2 Proteine), MMP-2 (zeige MMP2 Proteine), Ang-1 (zeige ANGPT1 Proteine), c-myc (zeige MYC Proteine) and CCND1 (zeige CCND1 Proteine)
In this study, FLT3 (zeige FLT3 Proteine) and NPM1 mutations were evaluated in adult Iranian patients with de novo cytogenetically normal acute myeloid leukemia (zeige BCL11A Proteine) and its correlations with clinical and laboratory parameters were also assessed.
These observations demonstrated that the expression and localization of NPM affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 (zeige PRDX6 Proteine) protein. The regulation axis of NPM/PRDX/ROS (zeige ROS1 Proteine) may provide a novel therapeutic target for cancer treatment.
ese results enhance our understanding of the molecular mechanisms that govern nucleoli formation by demonstrating that PPM1D regulates nucleolar formation by regulating NPM phosphorylation status through a novel signalling pathway, PPM1D-CDC25C-CDK1-PLK1
Data suggest that the direct interaction of several regions of nucleophosmin 1 (NPM1) C-terminal domain (CTD) with cellular membranes could be implicated in diseases where NPM1 is mutated and/or where its overexpression is cytoxic.
Mechanically, mutant NPM1 interacted with PML (zeige PML Proteine) and mediated its delocalization as well as stabilization contributing to elevated autophagic activity and leukemic cell survival in vitro.
Mutation analysis in NPM1 in acute myeloid leukemia (zeige BCL11A Proteine).
We conclude that the degradation of NPM1 and HEXIM1 (zeige HEXIM1 Proteine) through autophagy in certain AML (zeige RUNX1 Proteine) subsets contributes to the activation of the BET pathway in these cells.
In the current study, we demonstrate the existence of a negative feedback loop through which an increased B23 expression suppresses ERalpha (zeige ESR1 Proteine). Because suppression of ERalpha (zeige ESR1 Proteine) expression is a late event during estrogen-dependent endometrial tumorigenesis, the inhibition of nucleophisminmay represent a strategy to promote ERalpha (zeige ESR1 Proteine) re-expression that ultimately restores tumor sensitivity to hormonal therapy
molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3 (zeige FLT3 Proteine)-internal tandem duplications vs NPM1 (zeige GJA1 Proteine)/NRAS (zeige NRAS Proteine)-G12D-mutant acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) and functionally confirm the role of HOXA genes in NPM1c-driven AML (zeige RUNX1 Proteine).
NPM1 (zeige GJA1 Proteine)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (zeige CASP2 Proteine) activation cascade.
NPM1 (zeige GJA1 Proteine) knockdown decreased NF-kappaB (zeige NFKB1 Proteine)-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB (zeige NFKB1 Proteine) p65 (zeige NFkBP65 Proteine) to the gene promoters.
study suggests that although neurons need NPM1 (zeige GJA1 Proteine) for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1 (zeige EGR1 Proteine).
IDH2 (zeige IDH2 Proteine) and NPM1 (zeige GJA1 Proteine) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A Proteine) stem-like cells.
Lrrc34, a novel nucleolar protein (zeige MCRS1 Proteine), interacts with npm1 (zeige GJA1 Proteine) and ncl (zeige NCL Proteine) and has an impact on pluripotent stem cells
a function of NPM1 (zeige GJA1 Proteine) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (zeige DNMT1 Proteine) DNMT3A (zeige DNMT3A Proteine)
The data presented here support a novel role for NPM1 (zeige GJA1 Proteine) as a multilevel modulator of the base excision repair pathway.
Depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication.
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.
NLP is essential for the positioning of centromeres during cell division in Drosophila.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
nucleolar protein NO38
, nucleophosmin/nucleoplasmin family, member 1
, nucleolar phosphoprotein B23
, nucleolar protein B23.1
, nucleophosmin 1
, nucleophosmin/nucleoplasmin, 4
, chromatin decondensation protein 1
, nucleophosmin 1a (nucleolar phosphoprotein B23, numatrin)