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Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2alpha phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.
eukaryotic elongation factor 2 (zeige EEF2 Proteine) has a role in proliferation and invasion of lung squamous cell carcinoma
Increased phosphorylation of eIF2alpha in chronic myeloid leukemia (zeige BCL11A Proteine) cells stimulates secretion of matrix modifying enzymes.
a novel, positive role for PKR activation and eIF2alpha phosphorylation in human globin mRNA splicing, is reported.
Data show that eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2alpha-N-terminal domains (NTDs).
Data show that eIF5 (zeige EIF5 Proteine)-mimic protein (5MP) represses non-AUG translation by competing with translation initiation factor (zeige TIF1 Proteine) 5 (eIF5 (zeige EIF5 Proteine)) for the Met-tRNAi-binding factor eIF2 (zeige EIF2S1 Proteine).
This review consolidates current information regarding eIF2alpha phosphorylation in neurons and its impact in neurodegenerative diseases.
The PERK (zeige EIF2AK3 Proteine)-eIF2alpha-ATF4 (zeige ATF4 Proteine)-CHOP (zeige DDIT3 Proteine) signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
These data indicate that PERK (zeige EIF2AK3 Proteine) regulates radioresistance in oropharyngeal carcinoma through NF-kB activation-mediated phosphorylation of eIF2alpha
The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (zeige PKLR Proteine) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha (zeige EIF2S1 Proteine).
The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Caspase (zeige CASP3 Proteine)(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP (zeige DDIT3 Proteine) and activation of XBP-1 (zeige XBP1 Proteine) in RGC specifically, protects RGC somata and axons and preserves visual function.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP (zeige DDIT3 Proteine) activation, and enhanced macrophage beclin1 (zeige BECN1 Proteine) dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK (zeige EIF2AK3 Proteine) coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 (zeige PPP1R15A Proteine) complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
We hypothesize that the essential role of methionine-charged initiator tRNA in forming ternary complex is responsible for the robust ability of methionine deficiency to induce ATF4 (zeige ATF4 Proteine) and the ISR even in the absence of GCN2 (zeige EIF2AK4 Proteine) or eIF2alpha kinase activity.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (zeige PPP1CA Proteine) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (zeige ATF4 Proteine) expression. (eIF2a = eukaryotic initiation factor-2alpha (zeige EIF2S1 Proteine); PPP1CA (zeige PPP1CA Proteine) = protein phosphatase 1 catalytic subunit alpha; Atf4 (zeige ATF4 Proteine) = activating transcription factor 4 (zeige ATF4 Proteine))
ER stress-induced increase in ATF4 (zeige ATF4 Proteine) and CHOP (zeige DDIT3 Proteine) expression is initiated by an increase in Atf4 (zeige ATF4 Proteine) and Chop (zeige DDIT3 Proteine) mRNA, which is also dependent upon eIF2alpha phosphorylation.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
In conclusion, the immediate-early (zeige JUN Proteine) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.
Therapeutic modulation of eIF2alpha (zeige EIF2S1 Proteine) phosphorylation rescues TDP-43 (zeige TARDBP Proteine) toxicity in amyotrophic lateral sclerosis disease models.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, 65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C