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The findings show that DDX20 may promote the progression of prostate cancer through the NF-kappaB pathway.
In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected. However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes
DP103 defines metastatic potential of human breast cancers.
Impairment of miRNA-140 function due to a deficiency of DDX20, a miRNA machinery component, could lead to hepatocarcinogenesis
Gemin3 binds with p53, forming a complex, and plays an anti-apoptotic role by repressing the p53 expression in Saos-2 cells.
While DDX20 normally suppresses NF-kappaB activity by regulating NF-kappaB-suppressing miRNA-140 function, this suppressive effect was lost in DDX20-deficient cells.
we report that EBNA3C directly interacts with Gemin3 through its C-terminal domains
NANOS1-PUMILIO2 complex, together with GEMIN3 and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
Data show that the two motor neuropathy-associated mutant HspB8 forms have abnormally increased binding to Ddx20.
utilised a targeted screen to identify mRNA associated with SMN, Gemin2 and Gemin3 in the cytoplasm of a human neuroblastoma cell line, SHSY5Y
Gemin3 and Gemin4 function in Sm core assembly and correlate the activity of this pathway with Spinal Muscular Atrophy.
Ddx20 repressed Egr2-mediated transcriptional activation with significant promoter specificity
DP103 directly interacts with sumoylated SF-1 and is coupled to transcriptional repression by protein sumoylation.
Diverse functions for murine DP103, with an obligatory role during early embryonic development and also in modulation of steroidogenesis.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
, probable ATP-dependent RNA helicase DDX20
, DEAD box protein 20
, DEAD box protein DP 103
, DEAD-box protein DP103
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
, SMN-interacting protein
, component of gems 3
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20
, regulator of steroidogenic factor 1