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anti-Human Ataxin 2 Antikörper:
anti-Mouse (Murine) Ataxin 2 Antikörper:
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Human Monoclonal Ataxin 2 Primary Antibody für IF, WB - ABIN968504
Huynh, Del Bigio, Ho, Pulst: Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2. in Annals of neurology 1999
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Human Polyclonal Ataxin 2 Primary Antibody für ICC, IF - ABIN4281956
Abraham, Chan, Salvi, Ho, Hall, Vidya, Guo, Killackey, Liu, Lee, Brown, Mekhail: Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids. in Nucleic acids research 2016
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Cow (Bovine) Polyclonal Ataxin 2 Primary Antibody für ELISA - ABIN4254775
Dubois, Trynka, Franke, Hunt, Romanos, Curtotti, Zhernakova, Heap, Adány, Aromaa, Bardella, van den Berg, Bockett, de la Concha, Dema, Fehrmann, Fernández-Arquero, Fiatal, Grandone, Green, Groen et al.: Multiple common variants for celiac disease influencing immune gene expression. ... in Nature genetics 2010
Human Polyclonal Ataxin 2 Primary Antibody für ICC, IF - ABIN4281955
Kaehler, Isensee, Nonhoff, Terrey, Hucho, Lehrach, Krobitsch: Ataxin-2-like is a regulator of stress granules and processing bodies. in PLoS ONE 2012
SCA2 should be considered as a cause of typical Parkinson's disease phenotype even in the absence of cerebellar ataxia
Este es el primer estudio que (zeige DBT Antikörper) permite sugerir la asociacion del polimorfismo (CAG)n del gen (zeige GEN1 Antikörper) ATXN2 con (zeige DISP1 Antikörper) el desarrollo de DM tipo 2 pura (zeige PURA Antikörper) en poblacion de escasos recursos. Los alelos normales largos del VNTR son factores que (zeige DBT Antikörper) aumentan el riesgo para DM tipo 2 pura (zeige PURA Antikörper) en la poblacion mexicana analizada.
Deleterious non synonymous single nucleotide polymorphisms in ATXN2 Gene is associated with protein instability and conformational changes resulting in spinocerebellar ataxia.
Intermediate expansions of the CAG repeat (zeige CELF3 Antikörper) in ATXN2 are associated with amyotrophic lateral sclerosis. They are mostly associated with TDP-43 (zeige TARDBP Antikörper) proteinopathy, but not with 1C2-positive polyglutamine inclusions.
The findings of this sstudy suggest that ATXN2 may modify the known PINK1 (zeige PINK1 Antikörper) roles for mitochondrial quality control and autophagy during cell stress.
The conclusion pof (zeige POF1B Antikörper) this study , the transcriptome data do not exclude the role of ATXN2 mutated alleles in Parkinson disease but its decrease protein expression in both SCA2c and SCA2p patients suggest a potential involvement of this gene in Parkinson disease.
C9orf72 and ATXN2 repeat expansions cause ataxia, dementia, and parkinsonism in a Guyana family.
Intermediate length repeat expansions of CAG (polyQ) repeat in the ATXN2 gene have also been reported to increase the risk of developing ALS.
Intermediate ATXN2 trinucleotide repeat expansion in ALS does not predict age of onset but does predict disease risk.
While depletion of C9ORF72 (zeige C9ORF72 Antikörper) only has a partial deleterious effect on neuron survival, it synergizes with the toxicity of Ataxin-2 carrying intermediate length of polyglutamine expansions to induce motor neuron dysfunction and neuronal cell death.
Atxn2(-/-) mice showed an unstable rhythmicity of locomotor activity, but the level of PER1 (zeige PER1 Antikörper) and PER2 (zeige PER2 Antikörper) IR in the SCN (zeige SRI Antikörper) did not differ between genotypes.
Findings provide evidence that the physiological functions and protein interactions of ATXN2 are relevant for calcium-mediated excitation of Purkinje cells as well as for ATXN2-triggered neurotoxicity.
Results from global proteome and metabolome profiling of Atxn2-KO mouse liver and cerebellum indicates that ATXN2 modulates nutrition and basal metabolism.
work suggests that in Machado-Joseph disease, mutant ataxin-3 (zeige ATXN3 Antikörper) drives an abnormal reduction of ataxin-2 levels, which overactivates poly(A)-binding protein, increases translation of mutant ataxin-3 (zeige ATXN3 Antikörper) and other proteins and aggravates Machado-Joseph disease.
ATXN2 interacted selectively with RGS8 (zeige RGS8 Antikörper) mRNA. This interaction was impaired when ATXN2 harbored an expanded polyglutamine. Mutant ATXN2 also reduced RGS8 (zeige RGS8 Antikörper) expression in an in vitro coupled translation
The physiological role of ATXN2 subtly modifies the abundance of cellular translation factors as well as global translation.
FBXW8 (zeige FBXW8 Antikörper) and PARK2 (zeige PARK2 Antikörper) are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 (zeige FBXW8 Antikörper) expression is dysregulated
In KO mice, ATXN2 deficiency alters steady-state levels of Grb2 and Src, but does not block Grb2-dependent Ras signaling.
our data support the concept that expanded ATXN2 undergoes progressive insolubility and affects PABPC1 (zeige PABPC1 Antikörper) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8 (zeige FBXW8 Antikörper).
Ataxin-2 is not essential in development or during adult survival in the mouse, but leads to adult-onset obesity.
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.
, spinocerebellar ataxia type 2 protein
, trinucleotide repeat containing 13
, trinucleotide repeat-containing gene 13 protein
, spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
, spinocerebellar ataxia 2 homolog
, spinocerebellar ataxia type 2 protein homolog
, ataxin-2-like protein-like