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ESR1 (zeige ESR1 Proteine) inhibits the expression of Pitx2 gene by binding to a left side-specific enhancer region in Pitx2 gene and recruiting histone deacetylase 1 (zeige HDAC1 Proteine) to this region, leading to the suppression of Pitx2 gene in the left lateral plate mesoderm.
Data suggest that mutations affecting conserved non-coding elements of PITX2 may constitute an important class of mutations in patients with ASD (zeige ARSD Proteine) for whom the molecular cause of their disease have not yet been identified.
we propose that the Smad4 (zeige SMAD4 Proteine)-Pitx2-PPP2R2A (zeige PPP2R2A Proteine) axis, a new signaling pathway, suppresses the pancreatic carcinogenesis
Pitx2 is essential to maintain iHepSCs stem cell characteristics
Glaucoma prevalence and phenotype are characterized in a cohort of glaucoma patients and their family members with PITX2 variants.
Using an independent analytical platform, PITX2 methylation was validated as a prognostic biomarker in HNSCC patients, identifying patients that potentially benefit from intensified surveillance and/or administration of adjuvant/neodjuvant treatment, i.e. immunotherapy.
Pitx2 promoter region is methylated in atrial fibrillation patients.
Findings suggest ESR1 (zeige ESR1 Proteine) and PITX2 promoter methylation may be correlated with a worse survival of patients with breast cancer. The clinical utility of aberrantly methylated ESR1 (zeige ESR1 Proteine) and PITX2 could be a promising factor for the prognosis of breast cancer.
PITX2 methylation was significantly increased in tumor-positive biopsies and strongly correlated with International Society of Urological Pathology (ISUP) grade groups.
the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c expression via interaction with TFAP2a (zeige TFAP2A Proteine); such a pathway could ultimately contribute to AF susceptibility at the PITX2 locus associated with AF
Study showed that PITX3 (zeige PITX3 Proteine) and PITX2 were hypermethylated in prostate carcinomas (PCa (zeige FLVCR1 Proteine)) and significantly associated with established clinicopathologic parameters characteristic of PCa (zeige FLVCR1 Proteine).
data demonstrate that HTD, but not HTN, can impair Pitx2>>Wnt (zeige WNT2 Proteine) pathway providing thus a molecular link to AF
Defined a transcriptional architecture for atrial rhythm control organized as an incoherent feed-forward loop, driven by TBX5 (zeige TBX5 Proteine) and modulated by PITX2. TBX5 (zeige TBX5 Proteine)/PITX2 interplay provides tight control of atrial rhythm effector gene expression, and perturbation of the co-regulated network caused atrial fibrillation susceptibility.
Uncovering a Pitx2-Sox2 (zeige SOX2 Proteine)-Lef-1 (zeige LEF1 Proteine) transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.
Study reports that p27 (zeige CDKN1B Proteine) normally exerts a negative feedback on p21 expression: p27 (zeige CDKN1B Proteine) directly represses the expression of the transcription factor Pitx2 which in turn maintains decreased p21 levels. Consequently, in cells lacking p27 (zeige CDKN1B Proteine), de-repression of Pitx2 causes the up-regulation of p21 showing a new mechanism by which p27 (zeige CDKN1B Proteine) regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 and p21.
demonstrate a dose-dependent relation between Pitx2 expression and the expression of atrial fibrillation susceptibility genes
Data suggest a putative role of the homeobox protein PITX2 (PITX2B) isoform during ventricular septation as well as in the maturation of the right portion of the atrioventricular canal.
Pitx2 represses left-side expression of a conserved lncRNA Playrr. Pitx2 auto-regulation directs chromatin topology to coordinate left-right transcription and organogenesis.
The AP-2beta (zeige TFAP2B Proteine) transcription factor is an important effector of PITX2 function during corneal development, required for differentiation of corneal endothelium and establishment of angiogenic privilege.
Pitx2-deficient neonatal mouse hearts failed to repair after apex (zeige APEX1 Proteine) resection, whereas adult mouse cardiomyocytes with Pitx2 gain-of-function efficiently regenerated after myocardial infarction
Late zygotic oep (zeige TDGF1 Proteine) mutants have strongly reduced or absent pitx2 expression in the lateral plate mesoderm (LPM), but this expression can be rescued to strong levels by restoring oep (zeige TDGF1 Proteine) in midline structures only.
asymmetric expression of fatty acid elongase 6 gene is controlled by left right Nodal signaling and is independent of Pitx2 function in zebrafish
This study found PITX2 to be decreased in patients with sustained Atrial Fibrillation, suggesting a PITX2 loss of function mechanism in Atrial Fibrillation.
Antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. Restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry.
Pitx2, implicated in left-right asymmetry, possessed appropriate 'atypical' Pegasus (zeige IKZF5 Proteine) binding sites in its promoter.
Data indicate that retinoic acid (RA) induces the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b.
Pitx2 is essential for proper eye and craniofacial development in zebrafish.
Retinoic acid regulation of pitx2 is essential for coordinating interactions among neural crest, mesoderm, and developing eye.
Zebrafish pitx2 demonstrates conserved expression during ocular and craniofacial development. Thirteen conserved noncoding sequences positioned within a gene desert as far as 1.1 Mb upstream of the human PITX2
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
paired-like homeodomain transcription factor 2
, homeobox protein PITX2
, pituitary homeobox 2
, transcription factor Pitx2
, ALL1-responsive protein ARP1
, all1-responsive gene 1
, rieg bicoid-related homeobox transcription factor 1
, homeodomain transcription factor 2
, homeodomain transcription factor Pitx2
, BRX1 homeoprotein
, orthodenticle-like homeobox 2
, paired-like homeodomain transcription factor Munc 30
, paired-like homeodomain transcription factor 2a