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Human Monoclonal TPT1 Primary Antibody für IF, ELISA - ABIN563247
Chen, Huang, Yuan, Cheng, Zhou: Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. in Molecular biology and evolution 2014
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Human Monoclonal TPT1 Primary Antibody für ELISA, WB - ABIN521072
Sinthujaroen, Wanachottrakul, Pinkaew, Petersen, Phongdara, Sheffield-Moore, Fujise: Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo. in BBA clinical 2015
history of TCTP and purpose in studying it
REVIEW: structural analysis of TCTP and its interaction network from a structural perspective
Structure-Function Relationship of TCTP
REVIEW: Biological Functions and Regulation of TCTP
REVIEW: current knowledge of the TCTP interactome
Role and Fate of TCTP in Protein Degradative Pathways
Tctp is necessary for the accurate and timely development of axon projections during the formation of vertebrate retinal circuits via its association with the survival machinery of the axon
REVIEW: biochemical events leading to DNA damage by ionizing radiation and to its sensing and repair, and highlight TCTP's critical role in maintaining genomic integrity in response to DNA-damaging agents
REVIEW: role of TCTP as new therapeutic target in prostate cancer, in particular, therapy-resistant advanced PC and report the development of novel nanotherapy against TCTP that restore treatment-sensitivity in castration resistant PC that deserve to be tested in clinical trial
Role of TCTP for Cellular Differentiation and Cancer Therapy
REVIEW: History of Histamine-Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) Including a Potential Therapeutic Target in Asthma and Allergy
Results indicated that TPT1-AS1 promoted TPT1 expression by inducing the transcriptional activity of the TPT1 promoter without inhibiting TPT1 mRNA degradation.
Results provide evidence that the TCTP intrinsically disordered region is involved in remodeling the core domain surface to modulate its accessibility to its partners in response to a variety of cellular conditions.
These data suggest an important role for TCTP in regulating the critical vascular cell phenotypes that have been implicated in the pathobiology of Pulmonary arterial hypertension.
these results suggest that antigen and HRF dimer amplify intestinal inflammation by synergistically activating mast cells and indicate that HRF has potential as a therapeutic target in food allergy.
Data show that data demonstrate that tumor protein translationally-controlled 1 (TCTP) overexpression has a promotion effect on caudal type homeo box transcription factor 2 protein (CDX2) and villin1 protein (VIL1) expression.
Study findings suggested that TCTP promotes colorectal cancer metastasis through regulating the behaviors of HMGB1 and the downstream activation of the NF-kappaB signaling pathway.
The biological effects of Na,K-ATPase and TCTP interaction are reviewed.
The cells knocked down for TCTP show diminished invasiveness and migration under TGF-beta1 treatment. TGF-beta1 dependent TCTP expression is required for epithelial to mesenchymal transition in cells.
that TPT1 knockdown altered the BECN1 interactome, a representative MTOR-independent pathway, to stimulate autophagosome formation
The first crystal structure of murine HRF to 4.0A resolution, reveals a conserved fold. A model for the role of murine HRF in mast cell activation was created based on the human HRF structure.
Fortilin directly interacts with the cytoplasmic domain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of this stress sensor, and protects cells against apoptotic cell death at both cellular and whole animal levels.
TCTP-mediated spindle dynamics play a key role in maintaining oocyte quality during postovulatory aging. Overexpression of TCTP is sufficient to prevent aging-associated abnormalities in mouse oocytes.
Leads to the enhanced and previously un-described interaction of RACK1 and TCTP.
These data suggest the presence of a novel oxidative-stress-handling pathway where the anti-p53 molecule fortilin augments the peroxidase PRX1 by protecting it against degradation and inactivation of the enzyme.
results demonstrate that TCTP is a microtubule-associating protein required to regulate spindle microtubule dynamics during meiotic maturation in mouse oocytes.
TCTP over-expression-induced RhoA activation indicates that silencing of cellular TCTP may offer therapeutic approaches for the regulation of hypertension by inhibiting RhoA/Rho kinase pathway and modulating vascular contractility.
osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21
TPT1 is a p53 target gene that promotes cell survival.
Fortilin, induced in the proatherosclerotic microenvironment in macrophages, protects macrophages against Bax-induced apoptosis, allows them to propagate, and accelerates atherosclerosis.
Overexpression of translationally controlled tumor protein increases the severity of atherosclerosis and hypertension in apolipoprotein E knock-out mice
These findings suggest that TCTP might play an important role in the process of podocyte hypertrophy under diabetic conditions via the regulation of mTORC1 activity and the induction of cell-cycle arrest.
The TCTP downregulates the Oct4 expression by binding the Sf1 site of Oct4 promoter in mouse pluripotent cells.
TCTP may play a significant role in embryo implantation in mice
knockdown of Tctp resulted in increased amounts of P53 accompanied by a 50% reduction in the efficiency of tumor mammosphere formation
Identified a subset of IgE and IgG antibodies as TCTP(HRF)-interacting molecules in vitro. HRF was able to dimerize and bind to Igs via interactions of its N-terminal and internal regions with the Fab region of Igs.
Data indicate that Hprt, Rpl13a and Tpt1 are a set of stably expressed reference genes for accurate gene expression normalization in myocardial infarction studies in mice.
The Tpt1-Npm1 complex as a novel marker for highly proliferating cells, and offer further insight into the network that controls cellular fate.
pretreatment of donor cells with phosphorylated TCTP peptide has a beneficial effect on the potential of bovine somatic cell nuclei to develop into normal cloned calves.
A 'Y' transition single feature polymorphism in TCTP between Meishan and white composite swine breeds was identified by expression profiling using the in silico procedure Click-'N-SNP.
This work describes the cloning and structural analysis of a Tpt1 cDNA coding for the porcine translationally controlled tumor protein (TCTP) molecule and its expression in porcine cells and tissues.
Tctp supports the development of the retinotectal projection via its regulation of pro-survival signalling and axonal mitochondrial homeostasis, and establish a novel and fundamental role for Tctp in vertebrate neural circuitry assembly.
Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei.
REVIEW: Roles of the Translationally Controlled Tumor Protein (TCTP) in Plant Development
downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP
The 0.3 kb AtTCTP promoter can be used as a plant-derived constitutive promoter for the expression of selectable marker genes, which facilitates its use as an alternative to the 35S promoter for developing genetically engineered crops.
TCTP has molecular properties similar to animal TCTPs, such as tubulin- and calcium-binding, and that it functions in ABA-mediated stomatal movement, in addition to regulating the growth of plants.
data support a role of plant AtTCTP as a positive regulator of mitotic growth by specifically controlling the duration of the cell cycle.
The results identify TCTP as an important regulator of growth in plants and imply a function of plant TCTP as a mediator of TOR activity similar to that known in nonplant systems.
REVIEW: Tctp functions in Drosophila and discuss their implications in cancer
TCTP may promote the progression of epithelial ovarian cancer and reduce the sensitiveness of HO8910 cells to cisplatin.
TCTP has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
plant AtTCTP can fully rescue cell proliferation defects in Drosophila loss of function for dTCTP
Our studies identify TCTP as a direct regulator of Rheb and a potential therapeutic target for tuberous sclerosis disease.
Drosophila TCTP (dTCTP) displays GEF activity to Rheb and is essential for Rheb activation in organ growth
key role in controlling larval growth and development
BmTCTP as a dual-functional protein involved in both the cellular and the humoral immune response of the silkworm
Involved in calcium binding and microtubule stabilization (By similarity).
, histamine-releasing factor
, translationally-controlled tumor protein
, 21 kDa polypeptide under translational control
, translationally regulated transcript (21 kDa)
, lens epithelial protein
, translationally controlled tumor protein
, translationally-controlled tumor protein homolog
, growth-related translationally controlled tumor protein
, growth-related translationally-controlled tumor protein
, tumor protein, translationally-controlled 1
, translationally controlled tumor protein (TCTP)
, translationally controlled tumor protein 3
, translationally controlled tumor protein 4
, P23 tumor protein-like protein
, P23-like protein