CRY2 Proteine (CRY2)

Arabidopsis thaliana Cryptochrome 2 (Photolyase-Like) (CRY2) Interaktionspartner

1. The results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity of each other.

2. Verticillium dahliae PevD1 indirectly activates Arabidopsis CRY2 by antagonizing NRP (zeige NRP1 Proteine) functions. The promotion of CRY2-mediated flowering by a fungal effector outlines a novel pathway by which an external stimulus is recognized and transferred in changing a developmental program.

3. CRY2-CIB1 (zeige CIB1 Proteine) and CRY2-CRY2 interactions are governed by well-separated protein interfaces at the two termini of CRY2.

4. Exposure to blue light is required for an in vivo-association of CRY1 (zeige CRY1 Proteine) and CRY2 with COP1.

5. Data show that the effect of 3-bromo-7-nitroindazole (3B7N) treatment on gene expression in cryptochromes cry1cry2 is considerably smaller than that in the wild type, indicating that 3B7N specifically interrupts cryptochrome function in the control of seedling development in a light-dependent manner.

6. It describes minimal functional CRY2 and CIB1 (zeige CIB1 Proteine) domains maintaining light-dependent interaction and new signaling mutations affecting Arabidopsis thaliana cryptochrome 2 (AtCRY2) photocycle kinetics.

7. this study identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2.

8. the blue light-dependent CRY2 degradation is significantly impaired in the temperature-sensitive cul1 (zeige CUL1 Proteine) mutant allele (axr6 (zeige CUL1 Proteine)-3), especially under the non-permissive temperature.

9. For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.

10. Arabidopsis thaliana cry2 proteins containing Trp (zeige TBPL1 Proteine) triad mutations indeed undergo robust photoreduction in living cultured insect cells.

Human Cryptochrome 2 (Photolyase-Like) (CRY2) Interaktionspartner

1. CRY1 (zeige CRY1 Proteine)/2 serve as corepressors for many NRs (zeige SPNS1 Proteine).

2. data indicate an oncogenic role of miR (zeige MLXIP Proteine)-181d in CRC (zeige CALR Proteine) by promoting glycolysis, and miR (zeige MLXIP Proteine)-181d/CRY2/FBXL3 (zeige FBXL3 Proteine)/c-myc (zeige MYC Proteine) feedback loop might be a therapeutic target for patients with CRC (zeige CALR Proteine).

3. In the longitudinal analysis, CRY2 SNP rs61884508 was protective from worsening of problematicity of seasonal variations of mood disorder. In the cross-sectional analysis, CRY2 SNP rs72902437 showed evidence of association with problematicity of seasonal variations, as did SNP rs1554338 (in the MAPK8IP1 (zeige MAPK8IP1 Proteine) and downstream of CRY2).

4. The earlier reported association of CRY2 variants with dysthymia was confirmed and extended to major depressive disorder.

5. These results demonstrate that CRY2 stability controlled by FBXL3 (zeige FBXL3 Proteine) plays a key role in the regulation of human sleep wake behavior.

6. The FOXM1 (zeige FOXM1 Proteine) is a negative regulator of CRY2 in breast cancer via enhancing methylation in CRY2 promoter and its high expression is an independent predictor of favorable MR-free survival in ER+ breast cancer patients.

7. CRY2 and FBXL3 (zeige FBXL3 Proteine) cooperatively degrade c-MYC (zeige MYC Proteine) preventing the development of cancer.

8. The present study identified USP7 (zeige USP7 Proteine) and TDP-43 (zeige TARDBP Proteine) as the regulators of CRY1 (zeige CRY1 Proteine) and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork.

9. For the first time, we show that Cry 2 rs2292910 and MTNR1B (zeige MTNR1B Proteine) rs3781638 are associated with osteoporosis in a Chinese geriatric cohort.

10. Altered CRY1 (zeige CRY1 Proteine) and CRY2 expression patterns and the interplay with the genetic landscape in colon cancer cells may underlie phenotypic divergence.

Mouse (Murine) Cryptochrome 2 (Photolyase-Like) (CRY2) Interaktionspartner

1. Circadian clock cryptochrome proteins Cry1 (zeige CRY1 Proteine) and Cry2 regulate autoimmunity.

2. CRY1 (zeige CRY1 Proteine)/2 seem to repress a distinct subset of PPAR delta (zeige PPARD Proteine) target genes in muscle compared to the co-repressor NCOR1 (zeige NCOR1 Proteine). In vivo, genetic disruption of Cry1 (zeige CRY1 Proteine) and Cry2 enhances sprint exercise performance in mice.

3. CRY2 and FBXL3 (zeige FBXL3 Proteine) cooperatively degrade c-MYC (zeige MYC Proteine) preventing the development of cancer.

4. In vivo knockdown of Rfk (zeige RFK Proteine), Riboflavin (vitamin B2) kinase essential for FAD synthesis, altered the expression rhythms of CRY1 (zeige CRY1 Proteine), CRY2, and PER1 (zeige PER1 Proteine)

5. The present study identified USP7 (zeige USP7 Proteine) and TDP-43 (zeige TARDBP Proteine) as the regulators of CRY1 (zeige CRY1 Proteine) and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork.

6. Data show that cryptochrome Cry1 (zeige CRY1 Proteine) and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP (zeige AVP Proteine)) receptor signaling is required to impose circuit-level circadian function.

7. Data suggest that cryptochromes (Cry1 (zeige CRY1 Proteine) and Cry2) mediate periodic binding of Ck2b (zeige CSNK2B Proteine) (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (zeige ARNTL Proteine) protein) and thus inhibit Bmal1 (zeige ARNTL Proteine)-Ser90 phosphorylation by Ck2a (zeige CSNK2A1 Proteine) (casein kinase 2alpha).

8. Cry2 exerts a critical role in the control of depression-related emotional states and modulates the chronobiological gene expression profile in the mouse amygdala.

9. Cry1/Cry2-deficient mice had significantly lower N6- methyladenosine methylation of RNA and lost the circadian rhythm of N6-methyladenosine levels in RNA.

10. Data show that the intermolecular zinc finger is important for period circadian protein (PER2 (zeige PER2 Proteine))-cryptochrome 2 (CRY2) complex formation.