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Human CRY1 Protein expressed in Wheat germ - ABIN1350417
Santagata, Maire, Idbaih, Geffers, Correll, Holton, Quackenbush, Ligon: CRX is a diagnostic marker of retinal and pineal lineage tumors. in PLoS ONE 2009
CRYs' C termini are essential for nuclear localization but not necessary for the suppression of CLOCK/BMAL1 (zeige ARNTL Proteine) activation
we investigated the structure/function relationships of Xenopus laevis CRY1 (xCRY1) and xCRY2 (zeige CRY2 Proteine) in cultured cells
Cry1 is expressed in the olfactory bulb of newborn and juvenile rabbits.
CRY1 SNP rs714359 showed nominally significant association with the problematicity of seasonal variations (problematic vs. no variation) of mood disorder. The set-based analysis did not support these associations. However, the CRY1 haplotype TAG including rs714359 showed nominally significant association with the problematicity of seasonal variations in mood disorder.
CRY1 variants were not associated with major depressive disorder.
Our findings suggest that CLOCK and CRY1 polymorphisms might be involved in individual susceptibility to abdominal obesity in Chinese Han population.
Knockout-rescue embryonic stem cell-derived mouse reveals that CRY1 determines circadian period through both its degradation-dependent and -independent pathways.
The present study identified USP7 (zeige USP7 Proteine) and TDP-43 (zeige TARDBP Proteine) as the regulators of CRY1 and CRY2 (zeige CRY2 Proteine), underscoring the significance of the stability control process of CRY (zeige CRY2 Proteine) proteins for period determination in the mammalian circadian clockwork.
Altered CRY1 and CRY2 (zeige CRY2 Proteine) expression patterns and the interplay with the genetic landscape in colon cancer cells may underlie phenotypic divergence.
possible circadian rhythm in full-term placental expression
Given the distinct characteristics of the C-terminal tails of the CRY1 and CRY2 (zeige CRY2 Proteine) proteins, our study addresses a long-standing hypothesis that the ratio of these two CRY (zeige CRY2 Proteine) molecules affects the clock period.
Overexpression of CRY1 protects against the development of atherosclerosis via the TLR/NFkappaB pathway
Collectively, these data show that KPNB1 (zeige KPNB1 Proteine) is required for timely nuclear import of PER/CRY (zeige CRY2 Proteine) in the negative feedback regulation of the circadian clock.
hnRNP Q (zeige SYNCRIP Proteine) binds to mCry1 mRNA via the 5'UTR. Furthermore, hnRNP Q (zeige SYNCRIP Proteine) inhibits the translation of mCry1 mRNA, leading to altered rhythmicity in the mCRY1 protein profile.
In vivo knockdown of Rfk (zeige RFK Proteine), Riboflavin (vitamin B2) kinase essential for FAD synthesis, altered the expression rhythms of CRY1, CRY2 (zeige CRY2 Proteine), and PER1 (zeige PER1 Proteine)
Cryptochrome 1 in retinal cone photoreceptors suggests a novel functional role in mammals.
polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 (zeige PER2 Proteine) and CRY1
Data show that cryptochrome Cry1 and Cry2 (zeige CRY2 Proteine) expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP (zeige AVP Proteine)) receptor signaling is required to impose circuit-level circadian function.
uncovered a novel biological role for CUL4A (zeige CUL4A Proteine)-DDB1-CDT2 E3 ligase that regulates molecular circadian behaviors via promoting ubiquitination-dependent degradation of CRY1
Data suggest that cryptochromes (Cry1 and Cry2 (zeige CRY2 Proteine)) mediate periodic binding of Ck2b (zeige CSNK2B Proteine) (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (zeige ARNTL Proteine) protein) and thus inhibit Bmal1 (zeige ARNTL Proteine)-Ser90 phosphorylation by Ck2a (zeige CSNK2A1 Proteine) (casein kinase 2alpha).
Exposure to blue light is required for an in vivo-association of CRY1 and CRY2 (zeige CRY2 Proteine) with COP1.
Data suggest that cry1 mutation L407F exhibits hyperactivity which is not related to a higher FADH occupancy of the photoreceptor but is caused by a structural alteration close to the ATP-binding site.
Nitrogen signaling functions as a modulator of nuclear CRY1 protein abundance, as well as the input signal for the central circadian clock to interfere with the normal flowering process.
Data show that the effect of 3-bromo-7-nitroindazole (3B7N) treatment on gene expression in cryptochromes cry1cry2 is considerably smaller than that in the wild type, indicating that 3B7N specifically interrupts cryptochrome function in the control of seedling development in a light-dependent manner.
These data illustrate that in vivo modulation by metabolites in the cellular environment may play an important role in cryptochrome signaling.
For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.
CRY1 represses auxin biosynthesis in response to elevated temperature through PIF4.
CRY1 inhibits hypocotyl elongation in blue light through CNT1-mediated repression of the auxin/BR/GAresponsive gene expression.
Reactive oxygen species formation results from cry1 activation and induces cell death in insect cell cultures.
The study shows that ATP binding and aspartate protonation enhance photoinduced electron transfer in plant CRY1.
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.
cryptochrome 1 (photolyase-like)
, cryptochrome 2 (photolyase-like)
, cryptochrome 1