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Our data also suggested that apart from heart, the expression of HMGCS2 was also different in kidney and spleen between control and STZ treated mice. In conclusion, The HMGCS2 molecule may potentially be involved in T1D induced cardiac dysfunction.
several nutrients as well as specific nutritional related hormonal conditions are able to affect significantly HMGCS2 gene expression.
miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in Src expression and activation in a metabolically independent manner
HMGCS2 shares with ketone bodies common features in autophagic clearance of APP, suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21).
An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression
The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2.
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 enhances ketogenesis through HMGCS2 signaling activation by p38/NF-kB p65.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL)pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b.
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8-/- mice.
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
, HMG-CoA synthase
, hydroxymethylglutaryl-CoA synthase, mitochondrial
, 3-hydroxy-3-methylglutaryl coenzyme A synthase
, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
, hydroxymethylglutaryl-CoA synthase 2
, hydroxymethylglutaryl-CoA synthase, mitochondrial-like
, hydroxymethylglutaryl-CoA synthase
, hydroxymethylglutaryl-coa synthase
, putative hydroxymethylglutaryl-CoA synthase family protein
, 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2
, 3-hydroxy-3-methylglutaryl-CoA synthase 2
, 3-hydroxy-3-methylglutary-Coenzyme A synthase 2