anti-Cytochrome B-245, alpha Polypeptide (CYBA) Antikörper

Human Cytochrome B-245, alpha Polypeptide (CYBA) Interaktionspartner

1. This study observed an increase in the formation of intracranial aneurysm with p22phox-214T>C single nucleotide variation.

2. the CYBA C242T polymorphism is an independent determinant of endothelial function and subclinical atherosclerosis of the carotid arteries.

3. Metabolic syndrome in Brazilian NAFLD patients most likely results from common allelic variants in a large number of genes, including CYBA and NOX4, that interact with each other, each of which alone determines a modest risk.

4. The TT genotype of rs4673 in the CYBA gene was associated with Diabetic Peripheral Neuropathy in Type 1 Diabetes patients (OR 4.997, 95% CI 1.403-19.083, p = 0.016).

5. T allele carriers of C242T gene polymorphism might be predisposed to overt diabetic nephropathy [meta-analysis]

6. Three new mutations of CYBA gene in four of 22 Iranian patients with autosomal recessive-Chronic granulomatous disease were found.

7. Data indicate an association between the GA genotype of single nucleotide polymorphism rs3794624 in cytochrome b-245, alpha polypeptide (CYBA) with decreased tuberculosis susceptibility in two Chinese populations.

8. in patients with very severe chronic obstructive pulmonary disease the NADPH oxidase subunit p22phox is significantly reduced as compared to controls; p22phox is a key player in COPD and in hypoxic pulmonary vascular remodelling

9. data demonstrated that rs4673 transition in p22phox gene may be involved in susceptibility to coronary artery disease and could be applied as a potential biomarker for this disease.

10. Data suggest that an SNP in NADPH oxidase p22phox (C242T) is associated with nephropathy leading to macroalbuminuria in diabetic patients; this report is a meta-analysis of case-control genetic association studies. [META-ANALYSIS]

11. Together with the increased p22phox expression in lungs of asthmatic patients, findings demonstrate a crucial role of p22phox-dependent NADPH oxidase for the development of mucus hypersecretion and airway hyperresponsiveness in house dust mite-induced model of asthma.

12. Results showed that variations of the C242T polymorphism of the CYBA gene altered the risk of developing neonatal respiratory distress syndrome, retinopathy of prematurity, and bronchopulmonary dysplasia.

13. Suggest that the C242T gene polymorphism is associated with arterial stiffness. Additionally, this relationship could be modified by smoking dose.

14. In a family study of a patient with chronic granulomatous disease, the mutation in the CYBB gene was confirmed to be pathogenic, and the three variants in the CYBA gene were benign.

15. We demonstrated that rapid deletion of p22phox is possible and that the activity of Nox1 and Nox4 but not Nox5 exclusively depends on p22phox.

16. NOX5-p22phox complex drives monocytic differentiation into dendritic cells, and thus could be critical for immunity and inflammation.

17. PI3K/AKT signaling only occurs when FLT3-ITD is expressed at the plasma membrane and is required for the production of NOX-generated ROS. ER retention of FLT3-ITD resulted in NOX4 deglycosylation and p22(phox) protein degradation.

18. CYBA gene ()49A>G polymorphism modifies the risk of coronary artery disease

19. The study demonstrated that the genetic variants of rs9932581 and rs1049255 in CYBA might not be associated with preeclampsia.

20. p22phox C242T polymorphism has a possible role in changing the genetic susceptibility to late-onset AD in ApoE 4 carriers of northern Han Chinese origin.

Mouse (Murine) Cytochrome B-245, alpha Polypeptide (CYBA) Interaktionspartner

1. In p22phox(-/-) mice, hypoxic pulmonary vasoconstriction (HPV) was significantly impaired. In the chronic hypoxic setting, lack of p22phox was associated with improved right ventricular function and decreased pulmonary vascular remodelling.

2. Together with the increased p22phox expression in lungs of asthmatic patients, findings demonstrate a crucial role of p22phox-dependent NADPH oxidase for the development of mucus hypersecretion and airway hyperresponsiveness in house dust mite-induced model of asthma.

3. Identification of a PPAR-gamma --> NF-kappaB --> p22phox neuroprotective signaling cascade opens a new avenue for protecting the brain against ischemic insult.

4. Knockout of the cytochrome P450 reductase by CRISPR/Cas9 technology (POR(-/-)) in HEK293 cells overexpressing Nox4 or Nox5 did not interfere with ROS production in intact cells. However, POR(-/-) abolished the signal in NADPH-stimulated assays using membrane fractions from the very same cells. Moreover, membranes of rat smooth muscle cells treated with angiotensin II showed an increased NADPH-dependent signal with lucigen

5. p22phox mRNA expression was increased in diet-induced obese (DIO) mice.

6. The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.

7. Vascular hnRNP-C expression is regulated by ROS derived from NADPH oxidases and that the effects of NADPH oxidase on vascular activation are mediated in part by protein kinase CK1alpha.

8. Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 and p38-mitogen-activated protein kinase-dependent mechanisms in male type 2 diabetic mice.

9. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented.

10. renal expression of Nox-2, p22(phox), and p47(phox), components of NADPH oxidase, are upregulated in GSD-Ia mice compared with controls

11. cytochrome b558 expression is downregulated via the reduction of heme availability after NADPH oxidase is inhibited by HO-1

12. role in resistance to mucosal and systemic candidiasis of endogenous origin

13. LPS treatment enhanced protein levels of p22(phox), a catalytic subunit of NADPH oxidase, and increased NADPH oxidase activity and levels of superoxide radicals and hydrogen peroxide.

14. p22phox expression was increased during glucose-induced oxidative stress in microvascular endothelial cells.

15. collagen synthesis in cardiac fibroblasts involves a facilitative interaction between TGFbeta(1)-NADPH oxidase and LOX-1

16. mice of the nmf333 strain, animal model of p22(phox) deficiency, exhibit a compound phenotype consisting of both a CGD-like immune defect and a balance disorder caused by the aberrant development of gravity-sensing organs.

17. Suggest that a NOX4 isotype plus p22 phox account for the swelling-induced increase in the reactive oxygen species production in NIH3T3 cells.

18. p22phox is expressed in the retinal pigment epithelial cells and inner retinal neurons. A small-interfering RNA designed against p22phox efficiently reduced the expression of the protein in the eye when delivered by recombinant adeno-associated virus

19. Chronic intermittent hypoxia-induced pulmonary hypertension was associated with increased lung levels of the NADPH oxidase subunits, Nox4 and p22phox.

20. p22phox is involved in invadopodia formation; Tks5 and p22(phox) can associate with each other, suggesting that Tks5 is part of the Nox complex

Pig (Porcine) Cytochrome B-245, alpha Polypeptide (CYBA) Interaktionspartner

1. Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.

2. CRP inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H oxidase via p38 kinase activation

3. Reactive oxygen species generated by NADPH oxidase contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

Rabbit Cytochrome B-245, alpha Polypeptide (CYBA) Interaktionspartner

1. Angiotensin II inhibits the Na+/K+ pump via protein kinase c epsilon-dependent activation of NADPH oxidase subunits.