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alterations in the expression and subcellular localization of ATBF1, as a result of posttranscriptional modifications, are associated with malignant features of colon tumours.
Study identified DNA methylation (zeige HELLS Antikörper) (DNAm) site cg07786668 in ZFHX3 that is independently and significantly associated with myocardial infarction (MI) along with DNAm cg17218495 in SMARCA4 (zeige SMARCA4 Antikörper). These results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by cardiovascular disease-associated SNPs in these genes.
using in vitro prolactin induced lactogenic differentiation in an HC11 mouse cell model and an in vivo conditional knockout mouse model we showed that mouse Zfhx3 is essential for mouse mammary epithelial cell differentiation and mouse mammary gland development at the lactation stage through regulation of prolactin receptor expression and the downstream Jak2-Stat5 signaling pathway.
Increasing experimental data support that ZFHX3 gene plays a critical role in the pathogenesis of atrial fibrillation where it was found up-regulated. [review]
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for atrial fibrillation (A)F and AF-related phenotypes.
Nuclear localization of AT-motif binding factor 1 (ATBF1) indicates better prognosis of urothelial carcinoma.
Cellular localization of ATBF1 is correlated with its function in breast cancer. Nuclear ATBF1 was co-localized with chromosome during mitosis normally. Estrogen induced translocation of cytoplasmic ATBF1 to nuclei in MCF7.
The results suggest an additive effect of ZFHX3 and PTEN deletions on the development and progression of prostate neoplasia
Both ZFHX3 and PITX2c (zeige PITX2 Antikörper) regulate expression of NPPA (zeige NPPA Antikörper), TBX5 (zeige TBX5 Antikörper) and NKX2.5 (zeige NKX2-5 Antikörper).
In a Caucasian population, genetic variant rs7193343 SNP in ZFHX3 gene is associated with risk of atrial fibrillation.
findings demonstrate that ZFHX3 maintains an active role in setting the pace of the circadian clock in adult mice, thus sustaining a key role in the maintenance of stable circadian rhythms independent of any earlier developmental disruptions
ZFHX3 knock-down in atrial myocytes dysregulated calcium homeostasis and increased atrial arrhythmogenesis.
Data show that knock-out of zinc finger homeobox 3 (ZFHX3) interrupted lactogenesis, resulting in underdeveloped glands.
These findings provide in vivo evidence that ATBF1 is a tumor suppressor in the prostate
These data indicate that tachypacing decreased ATBF1, leading to enhanced STAT3 (zeige STAT3 Antikörper) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 and PIAS3 (zeige PIAS3 Antikörper).
findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells
Atbf1 heterozygous mice displayed reduced body weight, preweaning mortality, increased cell proliferation, and attenuated cytokeratin 18 (zeige KRT18 Antikörper) expression, indicating haploinsufficiency of Atbf1.
these results demonstrate that these phosphorylation sites on ATBF1 function as a defensive shield to calpain-1 (zeige CAPN1 Antikörper).
A novel signaling pathway that links ATM (zeige ATM Antikörper) via CREB (zeige CREB1 Antikörper) to the transcription factor ZFHX3, which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor beta (zeige PDGFRB Antikörper), is reported.
Atbf1, serves as a novel pituitary regulator for one of the two required enhancers as shown by genetic and in vitro analysis
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
zinc finger homeobox 3
, zinc finger homeobox protein 3-like
, AT-binding transcription factor 1
, AT-binding transcription factor1
, AT motif-binding factor 1
, alpha-fetoprotein enhancer binding protein
, alpha-fetoprotein enhancer-binding protein
, zinc finger homeobox protein 3
, zinc finger homeodomain protein 3
, AT motif binding factor 1
, AT motif-binding factor