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Human s100b Protein expressed in Escherichia coli (E. coli) - ABIN1097989
Cerofolini, Amato, Borsi, Pagano, Randazzo, Fragai: Probing the interaction of distamycin A with S100β: the "unexpected" ability of S100β to bind to DNA-binding ligands. in Journal of molecular recognition : JMR 2015
Data (including data from studies in knockout mice) suggest that S100b acting as a humoral factor impairs glycolysis in muscle (myoblasts, myotubes, and skeletal muscles) independent of insulin (zeige INS Proteine) action; this effect appears to be due to inhibition of Gapdh (zeige GAPDH Proteine) activity from enhanced poly(ADP-ribosyl)ation of Gapdh (zeige GAPDH Proteine). (S100B = S100 protein, beta polypeptide (zeige MS4A2 Proteine), neural; Gapdh (zeige GAPDH Proteine) = glyceraldehyde-3-phosphate dehydrogenase (zeige GAPDH Proteine))
Data (including data from studies using knockout mice) suggest that S100A1 (zeige S100A1 Proteine) (S-100 calcium-binding protein (zeige GUCA1B Proteine) A1 (zeige BCL2A1 Proteine), alpha chain (zeige FCGRT Proteine)) is involved in protein kinase A- (RIIalpha and RIIbeta (zeige PRKAR2B Proteine))-dependent signaling resulting in nuclear redistribution/influx of HDAC4 (histone deacetylase 4 (zeige HDAC5 Proteine)) in skeletal muscle fibers.
S100B inhibits C3H/10T1/2 murine embryonic mesenchyma.l cells into osteoblasts. S100B stimulates C3H/10T1/2 cell differentiation into adipocytes.
The results of this study showed that S100B affects behavioral despair in female mice through functional interaction with the 5-HT7 receptor.
Data show that S100B has direct effects on macrophages, enhancing particularly CCL22 (zeige CCL22 Proteine) and IL-1beta (zeige IL1B Proteine) expression and modulates the inflammatory response in uveoretinitis and this is likely to be, at least in part, via a direct effect on macrophages.
Data show that high glucose increased protein-protein interaction between Steap4 (zeige STEAP4 Proteine) and S100B in mesangial (MES13) cells.
S100A1 (zeige S100A1 Proteine)-KO exhibited increased right ventricular (RV) weight and elevated RV pressure in the absence of altered left ventricular filling pressures, increase in wall thickness of muscularized pulmonary arteries and a reduction in microvascular perfusion.
high glucoseinduced profibrotic genes (TGFbeta (zeige TGFB1 Proteine), type IV collagen (zeige COL4 Proteine) and fibronectin (zeige FN1 Proteine)) and cell hypertrophyrelated p21WAF1 are dependent on S100B.
S100A1 (zeige S100A1 Proteine) and S100B are dispensable for endochondral ossification during skeletal development.
S100A1 ablationalso reduced plaque associated and increased non-plaque associated PO4-Akt and PO4-GSK3beta staining.
Increased serum levels of S100B protein (and NSE (zeige ENO2 Proteine)) were observed postoperatively in patients with postoperative cognitive dysfunction.
high S100B expression in Multiple Sclerosis (MS) patient samples suggests its usefulness as a diagnostic biomarker for MS.
the underlying mechanism of S100B-mediated effects on cancer stem-like cell stemness was not dependent on its binding with a receptor for advanced glycation end products (RAGE (zeige AGER Proteine)), but might be through intracellular regulation, through the inhibition of p53 (zeige TP53 Proteine) expression and phosphorylation.
Data show that a high serum S100beta protein level, hypertension, and high low density lipoprotein-cholesterol (LDL-C) level were the independent risk factors for cerebral small vessel disease (SVD (zeige KCNJ13 Proteine)).
the serum concentrations of S100B are increased in bipolar disorder patients.
Levels of NSE (zeige ENO2 Proteine) and S100B are still elevated 1 year postpartum in women who have had preeclampsia in contrast to women with previous normal pregnancies.
In vitro experiments using repeated freeze-thaw procedures showed an intracellular up-regulation of S100B in normal and vitiligo (zeige MITF Proteine) melanocytes before an extensive release in the environment.
Acute paranoid schizophrenia inpatients present a day/night change of S100B serum levels at admission that disappears at discharge.
Compared to the control, the S100B/GAPDH (zeige GAPDH Proteine) mRNA ratio was significantly decreased in chronic liver diseases (p = 0.006) and most decreased in chronic hepatitis C patients (p = 0.023). We here evaluated S100B expression as a marker of hepatic nerves in patients with various chronic liver diseases, topographically and semi-quantitatively.
results indicate there were decreased S100B serum levels in bipolar patients in a manic phase after treatment.
As CSF (zeige CSF2 Proteine)-S100B levels in calves with neurologic diseases widely differed, the utility of CSF (zeige CSF2 Proteine)-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive.
S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE (zeige AGER Proteine)-dependent regulation of several inflammation-related events including activation and migration of microglia
X-ray crystallography was used here to characterize an interaction between Ca(2 (zeige CA2 Proteine))(+)-S100B and TRTK-12, a target that binds to the p53 (zeige TP53 Proteine)-binding site on S100B.
Intracellular S100B might modulate myoblast differentiation by interfering with MyoD (zeige MYOD1 Proteine) expression in an NF-kappaB (zeige NFKB1 Proteine)-dependent manner.
S100b activates guanylate cyclase in a calcium-dependent manner [review]
Structural studies in combination with biochemical data are used to develop a model for calcium-induced activation of human nuclear serine/threonine kinase (NDR (zeige STK38 Proteine)) kinase by S100B.
S100B shows a sufficient thermostability to resist pasteurization but not spry-drying in milk formulas for preterm and term infants.
Structures of pentamidine (Pnt (zeige ETS2 Proteine)) bound to Ca(2 (zeige CA2 Proteine)+)-loaded and Zn(2+),Ca(2 (zeige CA2 Proteine)+)-loaded S100B were determined by X-ray crystallography at 2.15 A (R(free)=0.266) and 1.85 A (R(free)=0.243) resolution, respectively.
The time course of S100B serum values following spinal cord decompression correlates with outcome; the initial degree of paresis is not a prognostic factor to predict outcome.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21\; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
S-100 protein alpha chain
, S-100 protein subunit alpha
, S100 calcium-binding protein A1
, protein S100-A1
, S-100 calcium-binding protein, beta chain
, S-100 protein subunit beta
, S100 calcium-binding protein, beta (neural)
, protein S100-B
, S-100 protein beta chain
, S100 calcium-binding protein B
, S100 protein, beta polypeptide
, S-100 calcium-binding protein beta subunit
, S100 calcium-binding protein beta (neural)
, S100 protein, beta polypeptide, neural
, S100 calcium binding protein, beta (neural)
, S100 calcium-binding protein, beta