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SRF and its cofactor MYOCD likely contribute to the hypertrophy of peripheral airway smooth muscle observed in equine asthmatic airways, while the remodeling of the central airways is more static or involves different transcription factors.
Equine primary fibroblasts were transformed by lentiviral transduction of equine myogenic differentiation 1 into fusion-competent myoblasts.
ACL (zeige ACLY Proteine) regulates the net amount of acetyl groups available, leading to alterations in acetylation of H3(K9/14) and H3(K27 (zeige KRT27 Proteine)) at the MYOD locus, thus increasing MYOD expression.
we found that MYOD transcription factor can upregulate miR (zeige MLXIP Proteine)-223 expression by binding to an E-box region of the gga-miR (zeige MLXIP Proteine)-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR (zeige MLXIP Proteine)-223
A high extent more than 25% of BRAF (zeige BRAF Proteine)(V600E) alleles may be associated with disease outcome in PTC (zeige F9 Proteine) patients.
we present the first report of MYOD1 (L122R) mutation in the largest cohort of 49 rhabdomyosarcomas reported so far, that are associated with a relatively aggressive clinical course
Analysis of human rhabdomyosarcoma revealed that MYF5 (zeige MYF5 Proteine) and MYOD are mutually-exclusively expressed and each is required for sustained tumor growth.
Cell transdifferentiation of primary skin fibroblasts by forced expression of myogenic transcription factor MyoD was performed by quantitative analyses of gene expression and chromatin accessibility profiles.
The results strongly suggest that the combination of MYCL plus MYOD1 may promote direct conversion of human fibroblasts into functional myoblasts that could potentially be used for regenerative therapy for muscle diseases and congenital muscle defects.
Analysis of the chromatin status of Cdkn1c (zeige CDKN1C Proteine) promoter and KvDMR1 in unresponsive compared to responsive cell types showed that their differential responsiveness to the MyoD-dependent induction of the gene does not involve just their methylation status but, rather, the differential H3 lysine 9 dimethylation at KvDMR1.
Data show that MeCP2 promotes gastric cancer (GC) cell proliferation via FOXF1 (zeige FOXF1 Proteine)-mediated Wnt5a (zeige WNT5A Proteine)/beta-Catenin (zeige CTNNB1 Proteine) signaling pathway, and suppresses GC cell apoptosis through MYOD1-mediated Caspase-3 (zeige CASP3 Proteine) signaling pathway.
Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting.
ACL (zeige APOC4 Proteine) regulates the net amount of acetyl groups available, leading to alterations in acetylation of H3(K9/14) and H3(K27 (zeige KRT27 Proteine)) at the MYOD locus, thus increasing MYOD expression.
Studies indicate MyoD displays function to regulate determination of skeletal muscle progenitors [Review].
Muscle regulatory transcription factor MyoD regulates the expression of the pro-apoptotic Bcl2 (zeige BCL2 Proteine) family member PUMA (zeige BBC3 Proteine) by binding to the promoter region of PUMA (zeige BBC3 Proteine). The increase in MyoD binding to the PUMA (zeige BBC3 Proteine) promoter as a consequence of culture in differentiation media (DM) is diminished in myoblasts silenced for MyoD expression. In myoblasts silenced for MyoD expression, p53 (zeige TP53 Proteine) binding to the PUMA (zeige BBC3 Proteine) promoter is diminished in response
our results indicate that HDAC11 (zeige HDAC11 Proteine) would suppress myoblast differentiation via regulation of MyoD-dependent transcription. These findings suggest that HDAC11 (zeige HDAC11 Proteine) is a novel critical target for controlling myoblast differentiation.
The data showed that Mettl3 (zeige METTL3 Proteine) is required for MyoD mRNA expression in proliferative myoblasts.
Gm7325, as a novel MyoD-target gene, is specifically induced in activated satellite cells, and may have an important role in skeletal myogenesis.
The ELF-EMFs did not affect C2C12 myoblast viability or proliferation rate. Conversely, at ELF-EMF intensity in the mT range, the myogenic process was accelerated, through increased expression of MyoD, myogenin (zeige MYOG Proteine), and connexin 43 (zeige GJA1 Proteine)
In this study, we identified ubiquitin-specific protease 4 (USP4 (zeige USP4 Proteine)), one of deubiquitinating enzymes, as a suppressor of MRFs by demonstrating that a knockdown of USP4 (zeige USP4 Proteine) enhances myogenesis by controlling MyoD and the level of myogenesis marker proteins in C2C12 cells... we propose that USP4 (zeige USP4 Proteine) is a key player in myogenic differentiation; it controls myogenic regulatory factors in a catalytic-independent manner
MyoD regulates the oxidative metabolic capacity of adult skeletal muscle;ChIP-seq analysis identified MyoD binding on the PGC (zeige PGC Proteine)-1b, but not PGC (zeige PGC Proteine)-1a, gene locus;MyoD cooperates with alternative NF-kappaB (zeige NFKB1 Proteine) to regulate PGC (zeige PGC Proteine)-1b transcription; MyoD and RelB (zeige RELB Proteine) co-occupy many other genes involved in aerobic respiration
LSD1 (zeige KDM1A Proteine) is required for the timely expression of MyoD in limb buds.
an Enhancer box and a binding site for a cooperative co-activator of MyoD are present in the promoter region of porcine PPARgamma (zeige PPARG Proteine).
Of the eight adult pig tissue types that were tested, the expression of Myf5 (zeige MYF5 Proteine) and MyoD1 was highest in the muscle tissue.
Single nucleotide polymorphisms in the MYOD1 and GDF8 (zeige MSTN Proteine) genes are associated with genetic transcription during myogenesis in pigs.
Therefore, this study demonstrated that the different regulatory adipogenic roles of MSTN (zeige MSTN Proteine) in ADSCs and MSCs act by differentially regulating PPARgamma (zeige PPARG Proteine) and MyoD expression.
Therefore, the g.489C>T and g.1264C>A SNPs in MYOD1 may be meaningful DNA markers that can be used for improving important porcine economic traits.
The total expression profile of MyoD and Pax7 (zeige PAX7 Proteine) genes suggests that higher muscularity in Pietrain pigs is associated with the presence of a greater number of active satellite stem cells compared to other breeds.
Exons and promoters are amplified and sequenced in the 5'UTR region of this gene.
Relative MYOD1 expression was not different, but MYOG (zeige MYOG Proteine) expression was higher in the (ligated-tube)crowded group embryos.
MYOD1 intron 1 DdeI polymorphism was not significantly associated with any meat quality traits tested
Transcript abundance for the muscle regulatory gene MYOD1 was lower in animals with more tender beef.
Bos taurus MYF5 (zeige MYF5 Proteine) activates MYF5 (zeige MYF5 Proteine) and MYOD1 expression in cultured fibroblasts.
results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles
n conclusion, hypoxia stimulates the proliferation of satellite cells and promotes their myogenic differentiation with MyoD playing an important role
Irxl1/Mkx (zeige MKX Proteine) can repress myoD expression through direct binding to its promoter and may thus play a negative regulatory role in muscle differentiation.
Myod in turn up-regulates cdkn1c (zeige CDKN1C Proteine), thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation
Myf5 (zeige MYF5 Proteine) and Myod function independently during cranial myogenesis.
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.
myogenic factor 3
, myogenic differentiation 1
, myoblast determination protein 1
, MYOD protein
, myogenic factor MyoD1
, MYOD1 homolog
, myoblast determination protein 1 homolog
, myogenic factor 1
, class C basic helix-loop-helix protein 1
, myogenic regulatory factor
, myogenic differenciation 1, transcription activator
, myogenic differenciation 1
, myoblast determination 1