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Human Polyclonal HDAC5 Primary Antibody für IHC, WB - ABIN362218
Lim, Luo, Koh, Yang, bin Abdul Kadir, Tan, Ye, Wang, Melamed et al.: Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by ... in Molecular and cellular biology 2007
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Human Polyclonal HDAC5 Primary Antibody für ChIP, WB - ABIN2668266
Basile, Mantovani, Imbriano: DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines. in The Journal of biological chemistry 2006
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Human Polyclonal HDAC5 Primary Antibody für IHC, WB - ABIN362746
Döppler, Storz, Li, Comb, Toker: A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. in The Journal of biological chemistry 2005
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Human Polyclonal HDAC5 Primary Antibody für IHC - ABIN966266
McKinsey, Zhang, Lu, Olson: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. in Nature 2000
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Human Polyclonal HDAC5 Primary Antibody für IP, IHC - ABIN223300
Yamaguchi, Chakraborty, Pasek, Molkentin, Meissner: Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. in American journal of physiology. Heart and circulatory physiology 2011
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Human Polyclonal HDAC5 Primary Antibody für ChIP, IP - ABIN4316754
Imbriano, Gurtner, Cocchiarella, Di Agostino, Basile, Gostissa, Dobbelstein, Del Sal, Piaggio, Mantovani: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. in Molecular and cellular biology 2005
Human Polyclonal HDAC5 Primary Antibody für ICC, IF - ABIN4316758
Baek, Park, Rhim, Park, Kim, Kim, Nam: Immunohistochemical Characterization of Histone Deacetylase as a Potential Prognostic Marker and Therapeutic Target in Endometrial Stromal Sarcoma. in Anticancer research 2016
These findings demonstrate a novel mechanism for deregulation of HDAC5 in non-small cell lung cancer (NSCLC)and suggest that miR5895p/HDAC5 pathway may represent a new prognostic biomarker and therapeutic target against NSCLC.
HDAC5 was extensively expressed in human BC tissues, and high HDAC5 expression was associated with an inferior prognosis.
HDAC5 is a negative predictor of disease-free and overall survival in pancreatic neuroendocrine tumor patients.
Interference with both glucose and glutamine (zeige GFPT1 Antikörper) supply in HDAC5-inhibited cancer cells significantly increases apoptotic cell death.
these results suggest that HDAC5 is critical in regulating LSD1 (zeige KDM1A Antikörper) protein stability through post-translational modification, and the HDAC5-LSD1 (zeige KDM1A Antikörper) axis has an important role in promoting breast cancer development and progression.
The expression of HDAC5 was significantly increased in endothelial cells (ECs) from patients with systemic sclerosis (SSc (zeige CYP11A1 Antikörper)) compared to healthy control endothelial cells. Silencing of HDAC5 in SSc (zeige CYP11A1 Antikörper) ECs restored normal angiogenesis. HDAC5 knockdown followed by ATAC (zeige XCL1 Antikörper)-seq assay in SSc (zeige CYP11A1 Antikörper) ECs identified key HDAC5-regulated genes involved in angiogenesis and fibrosis, such as CYR61 (zeige CYR61 Antikörper), PVRL2 (zeige PVRL2 Antikörper), and FSTL1 (zeige FSTL1 Antikörper).
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 (zeige HIPK2 Antikörper) in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5-homeodomain-interacting protein kinase-2 (zeige HIPK2 Antikörper)-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.
HDAC5 promotes cellular proliferation through the upregulation of cMet, and may provide a novel therapeutic target for the treatment of patients with Wilms' tumor.
HDAC5 and HDAC6 (zeige HDAC6 Antikörper) were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.
class IIa HDAC (zeige HDAC3 Antikörper) function could be used to enhance metabolic health in chronic diseases driven by physical inactivity.
HDAC5 emerges as a cellular conductor of MEF2C (zeige MEF2C Antikörper) and M6a (zeige GPM6A Antikörper) activity and is regulated by miR (zeige MLXIP Antikörper)-124 and miR (zeige MLXIP Antikörper)-9 to control neurite development.
This paper presents data for the first time directly supporting the role of HDAC5 as a scaffold recruiting a chromatin modifying co-repressor complex to specific transcription factors on unique gene promoters. These data for HDAC5 may reflect one of the functions of class IIa HDACs in transcriptional regulation distinct from its catalytic activity.
This study demonstrated that decreased HDAC5 function is able to exacerbate the long-term behavioral effects of adverse rearing environment in mice
As HDAC5 expression may help nullify AIS (zeige AR Antikörper) and identify progenitor cells, the precise delivery of miD2861 may serve as a vehicle for monitoring network remodeling with target specificity and signal sensitivity after drug exposure that identifies brain repair processes in adult animals.
This study demonstrated that mice with learned helplessness protocol-induced behavioral despair exhibited higher levels of HDAC5 and HDAC5 binding to the promoter region of BDNF (zeige BDNF Antikörper) exon IV resulting in the decreased expression of BDNF (zeige BDNF Antikörper).
inhibition of HDAC5 differentially regulates ghrelin (zeige GHRL Antikörper) and NUCB2/ nesfatin-1 (zeige NUCB2 Antikörper) expression by enhancing the acetylation and phosphorylation of Raptor (zeige RPTOR Antikörper), which subsequently suppress mTORC1 signaling
Results suggest a role for Hdac5 and Sirt2 (zeige SIRT2 Antikörper) in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression
loss of HDAC5 weakens Treg suppressive function and iTreg formation, as well as IFN-gamma (zeige IFNG Antikörper) production in CD8 (zeige CD8A Antikörper)+ T cells. Mice lacking HDAC5 do not develop spontaneous illness and do not have enhanced anti-tumor immunity.
Protein kinase D (zeige PRKD1 Antikörper)-HDAC5 pathway plays an important role in VEGF (zeige VEGFA Antikörper) regulation of gene transcription and angiogenesis
Regulation of flowering time by the histone deacetylase HDA5
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (zeige PKD2 Antikörper)-histone deacetylase 5-Kruppel-like factor signaling.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
, histone deacetylase 4
, histone deacetylase mHDA1
, histone deacetylase 5