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Rat (Rattus) DLG4 ELISA Kit für Sandwich ELISA - ABIN858839
Alam: Selective Brain-Targeted Antagonism of p38 MAPK? Reduces Hippocampal IL-1? Levels and Improves Morris Water Maze Performance in Aged Rats. in Journal of Alzheimer's disease : JAD 2015
Rat (Rattus) DLG4 ELISA Kit für Sandwich ELISA - ABIN435933
Lai, Yu, Qian, Wei, Lv, Xu: Chronic alcoholism-mediated impairment in the medulla oblongata: a mechanism of alcohol-related mortality in traumatic brain injury? in Cell biochemistry and biophysics 2013
Exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh (zeige DVL2 ELISA Kits) protein for Wg ligand reception in Drosophila. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh (zeige DVL2 ELISA Kits) protein from lysosomal degradation.
Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (zeige ACD ELISA Kits)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (zeige ACD ELISA Kits), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.
The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.
Loss of scrib (zeige SCRIB ELISA Kits), dlg and lgl had no effect on gonad formation, but Dlg and Scrib (zeige SCRIB ELISA Kits) in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.
Gliotactin and Discs large are co-regulated to maintain epithelial integrity.
Hts (zeige APCDD1 ELISA Kits) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.
Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.
DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization
Study provide evidence that scrib (zeige SCRIB ELISA Kits) and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib (zeige SCRIB ELISA Kits) and dlg act in a common pathway to regulate PFC (zeige CFP ELISA Kits) fate induction.
integrins act through CaMKII (zeige CAMK2 ELISA Kits) activation to control the localization of dlg in the development of NMJ synaptic morphology
This study demonstrated that in Chronic social defeat stress leads to changes PSD-95 in hippocampus of young mice.
The authors present evidence that synGAP (zeige SYNGAP1 ELISA Kits)-alpha1 regulates the composition of the postsynaptic density by restricting binding to the PDZ (zeige INADL ELISA Kits) domains of PSD-95.
In Fmr1 (zeige FMR1 ELISA Kits) KO neurons, Mdm2 (zeige MDM2 ELISA Kits) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C ELISA Kits) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM ELISA Kits) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 ELISA Kits) KO. Expression of a dephosphomimetic of Mdm2 (zeige MDM2 ELISA Kits) rescues PSD-95 ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 ELISA Kits) KO neurons.
tested the effect of five targeted mouse mutations on the assembly of known PSD95 interactors, Kir2.3 (zeige KCNJ4 ELISA Kits), Arc (zeige NOL3 ELISA Kits), IQsec2/BRAG1 (zeige IQSEC2 ELISA Kits) and Adam22 (zeige ADAM22 ELISA Kits)
Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI.
PSD95 and SYP (zeige PTPN11 ELISA Kits) may originate from the different sites, but they are closely related to the formation and maturation of synapse.
Expression levels of brain derived neurotrophic factor (zeige BDNF ELISA Kits), postsynaptic density 95 (zeige DLGAP2 ELISA Kits), and p-cyclic-AMP response element binding protein (zeige CREB ELISA Kits) levels were significantly elevated in the testosterone (T) group, but flutamide reduced the T-induced effects in these biomarkers to control levels.
The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN (zeige SYP ELISA Kits) and PSD95 expression, which is critical for structural synaptic plasticity.
critical roles of PSD-95 in regulating synaptic kainate receptors.
Phenylketonuric mice given a specific nutrient combination showed a significant reduction in PSD-95 expression in the hippocampus, specifically in the granular cell layer of the dentate gyrus, with a similar trend seen in the cornus ammonis 1 (CA1 (zeige CA1 ELISA Kits)) and cornus ammonis 3 (CA3 (zeige CA3 ELISA Kits)) pyramidal cell layer.
Phosphorylation at Y397 induced a significant increase in affinity for stargazing. The strategy presented here to generate site-specifically phosphorylated PDZ (zeige INADL ELISA Kits) domains provides a detailed understanding of the role of phosphorylation in the regulation of PSD95 interactions.
This study demonstrated that a significant decrease in the protein level of PSD-95 in major depression disorder.
These results indicate that PKC promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 (zeige MAPK8 ELISA Kits) and calcium/calmodulin-dependent kinase (zeige CAMK2 ELISA Kits) II and also by inducing expression of PSD-95 and synaptophysin (zeige SYP ELISA Kits).
The differences in cortical NMDAR (zeige GRIN1 ELISA Kits) expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.
Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders.
Data demonstrate a role for SNAP-25 (zeige SNAP25 ELISA Kits) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.
Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ (zeige INADL ELISA Kits) domains.
In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles
An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.
Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin (zeige SYP ELISA Kits) and before neuronal loss in patients with Alzheimer's disease.
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
, disc large
, discs large
, disk large
, lethal(1)benign wing imaginal disc neoplasm
, lethal(1)discs large
, lethal(2)discs large
, discs, large homolog 4
, postsynaptic density protein 95
, disks large homolog 4
, PSD-95 alpha 2b
, PSD-95 beta
, discs large homolog 4
, synapse-associated protein 90
, synapse-associated protein SAP90
, Tax interaction protein 15
, post-synaptic density protein 95