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alphaE-catenin recruits vinculin to adherens junctions more effectively than alphaN-catenin, partly because of its higher affinity for actin filaments.
CDF mutation disrupts the positioning of many, but not all, Purkinje cells during development.
A deletion in this protein causes cerebellar and hippocampal lamination defects and impaired startle reaction.
Alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture.
In the cortex, alpha-catenin is switched from alphaE-catenin in the VZ to alphaN-catenin II in the intermediate zone (IMZ).
alphaN-catenin expression is low in the ventricular zone and high in the developing cortical plate.
has diverse roles in the organization of the central nervous system, but only in limited portions of the brain
alpha-catenin has dual roles in intestinal tumorigenesis, a supporting role in tumor initiation, and a suppressive role in tumor progression
Single nucleotide polymorphisms in CTNNA2 show associations in Schizophrenia and general cognitive function.
One association in the CTNNA2 gene on chromosome 2p12 [rs1567532, hazard ratio (HR) = 1.75, 95% confidence interval (CI) 1.19-2.58, P = 0.005 for homozygotes for the minor allele] and one in the last intron of the RUNX2 gene on chromosome 6p21 (rs12209785, HR = 0.88, 95% CI 0.80-0.98, P = 0.014 for heterozygotes) are of particular relevance. These loci do not coincide with those that showed the strongest associations in t
SNP 50-kb upstream from CTNNA2 was associated with impulsivity in Native American sample.
Single nucleotide polymorphism in CTNNA2 is associated with breast cancer susceptibility.
CTNNA2 gene increases the risk of alcohol addiction in White women.
CTNNA2 and CTNNA3 are tumor suppressor genes frequently mutated in laryngeal carcinomas.
Common variants in CTNNA2 are associated with excitement-seeking and risk-taking.
CTNNA2 is differentially regulated by smoking in schizophrenic patients.
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity).
, catenin alpha-2
, alpha N-catenin
, cadherin associated protein
, catenin alpha 2
, cerebellar deficient folia
, neural alpha-catenin
, alpha-catenin-related protein
, cadherin-associated protein, related
, cancer/testis antigen 114
, catenin (cadherin-associated protein), alpha 1, 102kDa
, catenin, alpha 2