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We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (zeige CDO1 Proteine) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (zeige MCAM Proteine)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (zeige SHH Proteine)-receptor components, particularly PTCH1 (zeige PTCH1 Proteine), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (zeige SHH Proteine) proteins interact with cell adhesion molecule (zeige MCAM Proteine), down-regulated by oncogenes (CDO (zeige CDO1 Proteine)) and brother of CDO (BOC (zeige BOC Proteine)) in a conserved manner
CDO (zeige CDO1 Proteine) and BOC (zeige BOC Proteine) play a role in differentiation of cells in the skeletal muscle lineage
CDO (zeige CDO1 Proteine) and BOC (zeige BOC Proteine) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
Cdon deficiency causes hyperactive Wnt (zeige WNT2 Proteine) signaling leading to aberrant intercellular coupling and cardiac fibrosis.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (zeige SHH Proteine) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (zeige SHH Proteine) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (zeige EPRS Proteine) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (zeige MCAM Proteine) Cdo (zeige CDO1 Proteine) signaling is critical for Inward rectifier potassium channel Kir2.1 (zeige KCNJ2 Proteine) activities in the induction of myogenic differentiation.
PKN2 (zeige PKN2 Proteine) formed complexes with Cdo (zeige CDO1 Proteine), APPL1 (zeige APPL1 Proteine) and AKT (zeige AKT1 Proteine) via its C-terminal region and this interaction appeared to be important for induction of AKT (zeige AKT1 Proteine) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (zeige CDO1 Proteine) is required for the full Shh (zeige SHH Proteine) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (zeige PTCH1 Proteine).
Cx43 (zeige GJA1 Proteine) physically interacts with Cdo (zeige CDO1 Proteine) to form dynamic complexes during myoblast differentiation
Cdon is required to localize N-cadherin (zeige CDH2 Proteine) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (zeige SHH Proteine) protein, thereby limiting its dispersion.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
, cell adhesion molecule-related/down-regulated by oncogenes
, surface glycoprotein, Ig superfamily member
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, Cdon homolog (mouse)