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Cow (Bovine) Polyclonal CDON Primary Antibody für ELISA, ICC - ABIN4297093
Kang, Feinleib, Knox, Ketteringham, Krauss: Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. in Proceedings of the National Academy of Sciences of the United States of America 2003
Cdon is required to localize N-cadherin (zeige CDH2 Antikörper) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (zeige SHH Antikörper) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (zeige CDO1 Antikörper) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (zeige MCAM Antikörper)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (zeige SHH Antikörper)-receptor components, particularly PTCH1 (zeige PTCH1 Antikörper), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (zeige SHH Antikörper) proteins interact with cell adhesion molecule (zeige MCAM Antikörper), down-regulated by oncogenes (CDO (zeige CDO1 Antikörper)) and brother of CDO (BOC (zeige BOC Antikörper)) in a conserved manner
CDO (zeige CDO1 Antikörper) and BOC (zeige BOC Antikörper) play a role in differentiation of cells in the skeletal muscle lineage
CDO (zeige CDO1 Antikörper) and BOC (zeige BOC Antikörper) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh (zeige SHH Antikörper) signaling activity.
Mutation in the Cdon gene is associated with congenital nevus development.
Study assessed the role of the Shh (zeige SHH Antikörper) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (zeige EPRS Antikörper) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (zeige MCAM Antikörper) Cdo (zeige CDO1 Antikörper) signaling is critical for Inward rectifier potassium channel Kir2.1 (zeige KCNJ2 Antikörper) activities in the induction of myogenic differentiation.
PKN2 (zeige PKN2 Antikörper) formed complexes with Cdo (zeige CDO1 Antikörper), APPL1 (zeige APPL1 Antikörper) and AKT (zeige AKT1 Antikörper) via its C-terminal region and this interaction appeared to be important for induction of AKT (zeige AKT1 Antikörper) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (zeige CDO1 Antikörper) is required for the full Shh (zeige SHH Antikörper) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (zeige PTCH1 Antikörper).
Cx43 (zeige GJA1 Antikörper) physically interacts with Cdo (zeige CDO1 Antikörper) to form dynamic complexes during myoblast differentiation
Stim1 (zeige STIM1 Antikörper) protein levels were decreased in Cdo (zeige CDO1 Antikörper)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (zeige NFATC3 Antikörper) activation in Cdo (zeige CDO1 Antikörper)(-/-) myoblasts upon differentiation.
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I