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Human PLK3 Protein expressed in Wheat germ - ABIN1315440
Chen, Huang, Liu, Xu, Jiang: Design, synthesis, and evaluation of non-ATP-competitive small-molecule Polo-like kinase 1 (Plk1) inhibitors. in Archiv der Pharmazie 2015
Data indicate that elevated levels of Polo-like kinase 3 (Plk3)and pT273 caspase-8 (zeige CASP8 Proteine) are correlated with favorable clinical outcome in patients with anal squamous cell carcinoma (anal SCC (zeige CYP11A1 Proteine)) treated with concomitant chemoradiotherapy (CRT (zeige SLC6A8 Proteine)).
Knockout (KO) or knockdown of caspase-8 (zeige CASP8 Proteine), CD95 (zeige FAS Proteine) or FADD (zeige FADD Proteine) prevents activation of Plk3 upon CD95 (zeige FAS Proteine) stimulation, suggesting a requirement of a functional death-inducing signaling complex for Plk3 activation.
study revealed an interesting mutual regulation between Plk3 and SIAH2 (zeige SIAH2 Proteine) and uncovered a regulatory network that functions to fine-tune the cellular hypoxic response.
the differential effects of hypoxic stress on Plk3 activity in Human Limbal Stem and HCE (zeige RNGTT Proteine) cells. Instead of apoptosis, hypoxic stress suppresses Plk3 activity to protect limbal stem cells from death and to allow the process of Human Limbal Stem cell differentiation.
Data suggest that HOXA-AS2 (zeige ARSA Proteine) could be an oncogene (zeige RAB1A Proteine) for gastric cancer partly through suppressing P21 (zeige CDKN1A Proteine), PLK3, and DDIT3 (zeige DDIT3 Proteine) expression.
Plk3 is involved in the inhibition of cell proliferation and tumorigenesis, which may occur via interactions with p21 (zeige CDKN1A Proteine).
PLK3 predominantly is expressed in Cholangiocarcinomas (CCA (zeige FBN2 Proteine)) cells and that high PLK3 expression correlates with prolonged overall survival.
The role of Plk3 in oncogenesis: the aberrant expression of Plk3 was found in different types of tumors.
hyperosmotic stress-activated Plk3 elicited gammaH2AX (zeige H2AFX Proteine).
Plk3 binds to CtIP (zeige RBBP8 Proteine) phosphorylated at S327 via its Polo box domains, which is necessary for robust damage-induced CtIP (zeige RBBP8 Proteine) phosphorylation at S327 and subsequent CtIP (zeige RBBP8 Proteine) phosphorylation at T847.
Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression
Calcium- and integrin-binding protein 1 (zeige CIB1 Proteine) is involved in regulating endomitosis, perhaps through its interaction with Plk3
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha (zeige HIF1A Proteine)
Plk3 as a new player in the regulation of the PI3K/PDK1/Akt signaling axis by phosphorylation and stabilization of PTEN.
Data demonstrate that FGF-inducible kinase (Fnk) expression levels in transfected cells can be regulated by nuclear-cytoplasmic trafficking, ubiquitination, and proteosome-dependent degradation.
Plk3 localizes to the nucleolus and is involved in regulation of the G1/S phase transition.
Ectopic expression of the Plk3-kinase domain (Plk3-KD), but not its Polo-box domain or a Plk3-KD mutant, suppressed the nuclear accumulation of HIF-1 alpha (zeige HIF1A Proteine) induced by nickel or cobalt ions
The specificity of TTP (zeige ZFP36 Proteine) for promoting the degradation of Plk3 was demonstrated by the unaltered decay of Plk3 mRNA in cell
Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.
, serine/threonine-protein kinase PLK3
, FGF-inducible kinase
, polo-like kinase 3
, serine/threonine-protein kinase PLK3-like
, cytokine-inducible serine/threonine-protein kinase
, proliferation-related kinase
, cytokine inducible kinase
, serine-threonine kinase