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anti-Human ME1 Antikörper:
anti-Mouse (Murine) ME1 Antikörper:
anti-Rat (Rattus) ME1 Antikörper:
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Human Monoclonal ME1 Primary Antibody für IHC (p), ELISA - ABIN561774
Heart, Cline, Collis, Pongratz, Gray, Smith: Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. in American journal of physiology. Endocrinology and metabolism 2009
Human Polyclonal ME1 Primary Antibody für IHC, IHC (p) - ABIN4333382
Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011
Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues.
Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs).
The critical roles of miR-30a and ME1 in the development of KRAS-mutant colorectal cancer indicate therapy potentials for this subtype of cancer.
these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer.
ME1/ME2 (zeige CELSR1 Antikörper) expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.
ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance.
ME1 overexpression associates with unfavorable prognoses in patients with HCC (zeige FAM126A Antikörper), suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma.
essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells
the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME
p53 (zeige TP53 Antikörper) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 (zeige CELSR1 Antikörper) in human and mouse cells
Data suggest that Ad4BP (zeige NR5A1 Antikörper) plays role in regulation of intracellular NADPH (zeige FDXR Antikörper) concentration via transcription of Me1 and Mthfd2 (zeige MTHFD2 Antikörper) genes in adrenocortical cells. (Ad4BP (zeige NR5A1 Antikörper) = nuclear receptor subfamily 5 group A member 1 (zeige NR5A1 Antikörper); Me1 = malic enzyme 1; Mthfd2 (zeige MTHFD2 Antikörper) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
This study showed that (2)H-labeled tracers enable dissection of NADPH production routes across cell types and environmental conditions.
ME1 expression was found to be mutant-KRAS-associated in an NSCLC mouse model.
p53 (zeige TP53 Antikörper) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 (zeige TCF4 Antikörper) in human and mouse cells
cytosolic or mitochondrial isoforms of malic enzyme do not affect glucose-stimulated insulin (zeige INS Antikörper) secretion from rodent islets
although ME1 overexpression augments anaplerosis and glucose stimulated insulin (zeige INS Antikörper) secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin (zeige INS Antikörper) secretion in pancreatic islets
This lack of consistency across families, combined with the fact that the ME1 mutation is synonymous and that the two DECR1 (zeige DECR1 Antikörper) polymorphisms are conservative, suggests that the associations found are not causative.
Transcript level of the porcine ME1 gene is affected by SNP in its 3'UTR (zeige UTS2R Antikörper), which is also associated with subcutaneous fat thickness.
Malic enzyme 1 genotype is associated with backfat thickness and meat quality traits in pigs.
Six novel SNPs, five in ME1 and one in NR0B2 (zeige NR0B2 Antikörper), were identified as candidates that have effects on meat and carcass quality traits.
ME1-Dra I genotypes had a significant effect on cooking loss.
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
Malic enzyme, cytoplasmic
, NADP-dependent malic enzyme
, malate dehydrogenase
, malic enzyme 1, soluble
, pyruvic-malic carboxylase
, malic enzyme, supernatant
, cytosolic malic enzyme 1
, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
, malate dehydrogenase decarboxylase (NADP+)
, malic enzyme 1, NADP(+)-dependent, cytoplasmic (cytosolic, soluble)
, malic enzyme 1, NADP(+)-dependent, cytosolic
, cytosolic malic enzyme 1-like
, NADP-dependent malic enzyme-like