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Purification and characterization of the plastid-localized NAD-dependent malate dehydrogenase from Arabidopsis thaliana
The critical role of plastidial NAD-specific MDH isoform in Arabidopsis (Arabidopsis thaliana) plants, is reported.
Arabidopsis thaliana mutants lacking the NADP-malate dehydrogenase have lost the reversible inactivation of catalase (zeige CAT Proteine) activity and the increase in H2O2 levels when exposed to high light.
plastid-localized NAD-dependent malate dehydrogenase is crucial for energy homeostasis in developing Arabidopsis thaliana seeds
mMDH (zeige MDH2 Proteine) has a role in maximizing photorespiratory rate.
ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production.
The chromosome 18q21 deletion in nearly one third of pancreatic adenocarcinomas eliminates not only the tumor suppressor SMAD4 (zeige SMAD4 Proteine), but also neighboring genes with important cellular roles, such as ME2
deletion of malic enzyme 2 (zeige NAD-ME Proteine) confers collateral lethality in pancreatic cancer
ME1 (zeige ME1 Proteine)/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions.
Data indicate that malic enzyme 2 (zeige NAD-ME Proteine) knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene (zeige RAB1A Proteine) protein akt (zeige AKT1 Proteine) (PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)) signaling.
ME2 might be an important factor in melanoma progression and a novel biomarker of invasion.
Three SNP alleles in BRD2 (zeige BRD2 Proteine), Cx-36 (zeige GJD2 Proteine), and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.
p53 (zeige TP53 Proteine) represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 (zeige ME1 Proteine) and ME2 in human and mouse cells
Depletion of malic enzyme 2 (zeige NAD-ME Proteine) induced erythroid differentiation in human erythroleukemia cells.
An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.
, malic DH
, malic enzyme b
, oxidoreductase, putative
, malate dehydrogenase
, NAD-dependent malic enzyme, mitochondrial
, pyruvic-malic carboxylase