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Genes coregulated by CDK8 (zeige CDK8 Proteine)/19 and NFkappaB (zeige NFKB1 Proteine) include IL8 (zeige IL8 Proteine), CXCL1 (zeige CXCL1 Proteine), and CXCL2 (zeige CXCL2 Proteine).
Moreover, it identified CDK19 and CDK8 (zeige CDK8 Proteine) to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer.
High CDK19 expression is associated with osteosarcoma.
On stimulation of TLR9 (zeige TLR9 Proteine), CDK8 (zeige CDK8 Proteine)/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB (zeige NFKB1 Proteine) and C/EBPbeta (zeige CEBPB Proteine).
Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog).
Mediator-associated kinases CDK8 (zeige CDK8 Proteine) and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML (zeige RUNX1 Proteine)) cells
Microarrays identified target genes for each CDK (zeige CDK4 Proteine), and we selected six genes: two target genes of CDK8 (zeige CDK8 Proteine), two target genes of CDK19 and two genes that were targets for both.
CDK8 (zeige CDK8 Proteine) and CDK19, individually interact with PRMT5 (zeige PRMT5 Proteine) and WDR77 (zeige WDR77 Proteine), and their interactions with PRMT5 (zeige PRMT5 Proteine) cause transcriptional repression of C/EBPbeta (zeige CEBPB Proteine) target genes.
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex.
CDC2-related protein kinase 6
, CDK8-like cyclin-dependent kinase
, cell division cycle 2-like 6 (CDK8-like)
, cell division cycle 2-like protein kinase 6
, cell division protein kinase 19
, cyclin dependent kinase 19 variant 2
, cyclin-dependent kinase (CDC2-like) 11
, cyclin-dependent kinase 11
, death-preventing kinase
, cyclin-dependent kinase 8