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Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN413012
Barlic, Zhu, Murphy: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Human APOA1 Protein expressed in Escherichia coli (E. coli) - ABIN2003220
Soutar, Hawkins, Vigushin, Tennent, Booth, Hutton, Nguyen, Totty, Feest, Hsuan: Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. in Proceedings of the National Academy of Sciences of the United States of America 1992
Show all 4 Pubmed References
Data suggest that Apolipoprotein A1 (ApoA-1) might be a promising therapeutic target to reduce recurrence and metastasis for hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) patients after resection.
The generated structures provide evidence for the discoidal, antiparallel arrangement of apoA-I in nascent HDL (zeige HSD11B1 Proteine), and propose two preferred conformations of the flexible N-termini
identified that apolipoprotein-A1 and haptoglobin (zeige HP Proteine) had significant predictive values for the prediction of recovery at 12 weeks in DILI, enabling the construction of a new prognostic panel, the DILI-ActiTest, which needs to be independently validated
ApoA1 is associated with neurite outgrowth after mechanical injury by mediating polymerisation of actin and restricting inflammatory responses after injury which are deleterious to healing.
A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I
Lower ApoA1 improves the risk prediction of new type 2 diabetes
Following ETC-216 administration to normal human volunteers, an initial dose-dependent HDL (zeige HSD11B1 Proteine)-C elevation was observed. Thereafter, subjects transiently acquired a lipoprotein profile similar to that of AIM carriers, including reduced HDL (zeige HSD11B1 Proteine)-C and mild hypertriglyceridemia.
The different anti-inflammatory mechanisms of the ApoA-I cysteine mutants might be associated with the regulation of ATF3 (zeige ATF3 Proteine) level.
Anti-apoA-1 IgG are independent predictors of nonfatal incident coronary artery disease in the general population. The strength of this association is dependent on a functional polymorphism of the CD14 receptor gene, a finding suggesting a gene-autoantibody interaction for the development of CAD.
ABCA1 (zeige ABCA1 Proteine)-derived nascent high-density lipoprotein-apolipoprotein AI and lipids metabolically segregate.
apoA-I/ABCA1 (zeige ABCA1 Proteine)-mediated cholesterol efflux without STAT3 (zeige STAT3 Proteine) activation can reduce proinflammatory cytokine expression in macrophages.
a novel protective role for ApoA-I in colitis and CAC (zeige SLC25A20 Proteine)
Our results assign a novel role for 4F(apoA-I mimetic peptide ) as a modulator of the TICE pathway and suggest that the anti-inflammatory functions of 4F may be a partial consequence of the codependent intestinal transport of both 4F and cholesterol.
Preincubation of endothelial cells with apoA-I protected against the TNF-alpha (zeige TNF Proteine)-induced inhibition of HTR (zeige F2R Proteine)-8/SVneo (trophoblast) cell integration into endothelial (UtMVEC) networks. These data suggest that a healthy lipid profile may affect pregnancy outcomes by priming endothelial cells in preparation for trophoblast invasion.
Reductions in Dio1 (zeige DIO1 Proteine) expression reduce the expression of ApoA-I in a 3,5,3'-triiodothyronine-/thyroid hormone (zeige PTH Proteine) response element-independent manner.
apoA-1 deficiency generates changes in the bone cell precursor population that increase adipoblast, and decrease osteoblast production resulting in reduced bone mass and impaired bone quality
This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 (zeige ABCA1 Proteine) expression and ABCA1 (zeige ABCA1 Proteine)-mediated cholesterol efflux to apoAI, which is not involved by CD36 (zeige CD36 Proteine) expression either.
Mass spectrometry analysis of peptides derived from chemically crosslinked HDL (zeige HSD11B1 Proteine)-SAA (zeige SAA1 Proteine) particles detected multiple crosslinks between apoA1 and SAA (zeige SAA1 Proteine), indicating close proximity (within 25 A) of these two proteins on the HDL (zeige HSD11B1 Proteine) surface, providing a molecular and structural mechanism for the simultaneous binding of heparin to apoA1 and SAA (zeige SAA1 Proteine).
results demonstrate that double deletion of Apoe (zeige APOE Proteine) and Apoa1 ameliorated the amyloid pathology.
insulin (zeige INS Proteine) secretion and tissue rejuvenation activities of WT-reconstituted high-density lipoproteins were nearly depleted by fructosylation, but V156K-rHDL did not lose its beneficial activity.
The NABB system using engineered zebrafish apo A-I is a native-like membrane mimetic system for G-protein-coupled receptors.
Binding of apoA-I to ectopic F(0)F(1) ATPase (zeige ATP5E Proteine) triggers the generation of ADP, which via activation of the purinergic receptor P2Y (zeige P2RY1 Proteine)(12) stimulates the uptake and transport of HDL (zeige HSD11B1 Proteine) and initially lipid-free apoA-I by endothelial cells.
the model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 (zeige ABCA1 Proteine) and then further processed by ABCA1 (zeige ABCA1 Proteine)-independent mechanisms.
This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
The molar ratio ApoE (zeige APOE Proteine)/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
Alterations in the Apo A (zeige APOA Proteine)-I pattern is a good indicator of the presence and severity of infectious diseases in the pig.Lower overall amounts of Apo A (zeige APOA Proteine)-I were observed in Salmonella typhimurium and Escherichia coli infections.
down-regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 (zeige IL6 Proteine) and tumor necrosis factor-alpha (zeige TNF Proteine)
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.
, apolipoprotein A1
, apolipoprotein A-1
, preproapolipoprotein A-I
, apolipoprotein A-I
, apolipoprotein A-I preproprotein
, Apolipoprotein A1
, apolipoprotein A-I-like
, Apolipoprotein A-I