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AP-1 (zeige JUN Proteine)/sigma1A (zeige AP1S1 Proteine)-ArfGAP1 (zeige ARFGAP3 Proteine)-Rabex-5 complex formation leads to more endosomal Rabex-5 and enhanced, Rab5 (zeige RAB5A Proteine)(GTP (zeige AK3 Proteine))-stimulated Vps34 (zeige PIK3C3 Proteine) PI3-kinase (zeige PIK3CA Proteine) activity, which is essential for multivesicular body endosome formation.
findings reveal a key role for RABGEF1 in dampening keratinocyte-intrinsic MYD88 (zeige MYD88 Proteine) signaling and sustaining epidermal barrier function
Knockdown of RABEX-5 also inhibited wound healing, migration and the invasive abilities of gastric cancer cells.
Hyperinsulinemia induced insulin (zeige INS Proteine) resistance in 3T3-L1 adipocytes by retaining GLUT4 (zeige SLC2A4 Proteine) in a Rab5 (zeige RAB5A Proteine)-activity-dependent compartment.
Kruppel-like factor 5 (zeige KLF5 Proteine) is indispensable for adhesion, homing, lodging and retention of haematopoietic stem cells and progenitors in the bone marrow through Rab5 (zeige RAB5A Proteine)-dependent post-translational regulation of beta1/beta2 integrins
Rab5 (zeige RAB5A Proteine) is required for phagocytosis of heat-inactivated Pseudomonas aeruginosa by macrophages.
Rabex-5 regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (zeige RAB5A Proteine), which is localized in both axons and dendrites, and Rab17 (zeige RAB17 Proteine), which is localized in dendrites alone
a novel mechanistic insight into how Rabex-5 regulates internalization and postendocytic trafficking of ubiquitinated L1 destined for lysosomal degradation.
Data show that RabGEF1 can negatively regulate thymic stromal lymphopoietin (TSLP (zeige TSLP Proteine)) production in vivo and that excessive production of TSLP (zeige TSLP Proteine) contributes to many of the phenotypic abnormalities in Rabgef1-/- mice.
Data reveal the affinity of Rabex-5/Rabaptin-5/Rab5 (zeige RAB5A Proteine)-GTP (zeige AK3 Proteine) interaction in the cell, which is quantitatively related to the Rabex-5 concentration for the onset of the indirect positive feedback pathway.
The authors demonstrate that RABGEF1, the upstream factor of the endosomal Rab GTPase (zeige RAB6A Proteine) cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin (zeige PARK2 Proteine). RABGEF1 directs the downstream Rab (zeige HRB Proteine) proteins, RAB5 (zeige RAB5A Proteine) and RAB7A (zeige RAB7A Proteine), to damaged mitochondria, whose associations are further regulated by mitochondrial Rab (zeige HRB Proteine)-GAPs.
RABEX-5 mRNA expression was significantly upregulated in colorectal cancer tissues.
we identify Rabex-5 as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon (zeige CRBN Proteine) enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs.
RABGEF1 mediates recycling endosome fusion with GAS-containing autophagosome-like vacuoles through the STX6-VAMP3-VTI1B complex; SNAREs are involved in autophagosome formation in response to bacterial infection
The results contradict the model of feedback activation of Rab5 (zeige RAB5A Proteine) and instead indicate that Rbpt5 is recruited by both Rabex5 recognizing ubiquitylated cargo and by Rab4 (zeige RAB4A Proteine) to activate Rab5 (zeige RAB5A Proteine) in a feed-forward manner.
RABEX-5 is a potential useful indicator and predicts a poor long-term prognosis for small cell lung cancer(SCLC), which should be considered in defining the prognosis with other well-known prognosticators in C-SCLC patients
Expression of RABEX-5 is significantly higher in gastric cancer tissues and is associated with tumor size and lymph node metastasis.
analysis of Rabex-5 GEF activation by Rabaptin-5
This implies that Rap (zeige LRPAP1 Proteine) regulates endothelial barrier function by dual control of cytoskeletal tension. The molecular details of the signaling pathways are becoming to be elucidated
these data suggest differential physiological roles of the two ubiquitin binding domains in Rabex-5.
Receptor recycling is mediated by AP-1 (zeige JUN Proteine)/clathrin-coated vesicles and regulated by rab4 (zeige RAB4A Proteine) and rabaptin-5/rabex-5.
Rabex-5 is a ubiquitin ligase that binds ubiquitin and undergoes ubiquitination; the N-terminal region of Rabex-5 (residues 1-76) is important for ubiquitin binding and ubiquitination.
The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites
Rabex-5 can target to early endosomes via the EET domain and activate Rab5 in a Rabaptin-5-independent manner in vivo.
Data show that ubiquitin binding is essential for the recruitment of Rabex-5 from the cytosol to endosomes, independently of its guanine nucleotide exchange factor (zeige ARHGEF12 Proteine) activity and of Rab5 (zeige RAB5A Proteine).
RABGEF1 forms a complex with rabaptin-5 (RABPT5\; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\; MIM 179512) (Horiuchi et al., 1997
Rab5 exchange factor
, Ras negative regulator Rabex-5
, Ras negative regulator Rabex-5/Rin2
, rab5 GDP/GTP exchange factor
, rabaptin-5-associated exchange factor for Rab5
, Rab5 guanine nucleotide exchange factor Rabex-5
, RAB guanine nucleotide exchange factor (GEF) 1
, Rab5 GDP/GTP exchange factor
, BTB/POZ domain-containing protein KCTD7
, RAB guanine nucleotide exchange factor (GEF) 1 L homeolog