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PAXIP1 and 53BP1 (zeige TP53BP1 Proteine) protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced breast cancer tumors.
PAXIP1 is involved in sensitizing lung cancer cells to the WEE1 (zeige WEE1 Proteine) inhibitor AZD1775 in combination with platinum-based treatment.
PTIP promotes double-strand break repair through a direct role in homologous recombination.
PPM1B (zeige PPM1B Proteine) can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation.
uncovered a nuclease (zeige DCLRE1C Proteine), Artemis (zeige DCLRE1C Proteine), as a PTIP-binding protein
PITX2 (zeige PITX2 Proteine) and PTIP co-occupy the promoter of the PITX2 (zeige PITX2 Proteine)'s transcriptional target.
Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability.
a new clue to identify the role of PTIP in DNA damage pathway
PTIP controls expression of P (zeige PPARG Proteine)PARgamma and C/ (zeige CEBPA Proteine)EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis.
PTIP (PAXIP1) is a strong inhibitor of the trans-activation activities of Pax2A and Pax2B on the glucagon (zeige GCG Proteine) gene promoter and p8 binding to PTIP prevents inhibition of this promoter.
Immunodepletion of PTIP/Swift from Xenopus extracts prevented efficient proliferating cell nuclear antigen (zeige PCNA Proteine) ubiquitination and polymerase eta (zeige POLH Proteine) recruitment to chromatin during replicative stress
The role for PTIP in promoting sterile transcription at the Igh locus.
a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
Study concludes that 53BP1 (zeige TP53BP1 Proteine) promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP.
PAXIP1 controls distinct transcriptional programs during DP differentiation necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural killer T cell development.
PTIP plays an important role in the DNA repair process associated with the development of mature spermatozoa.
PTIP stabilizes the Pax5 (zeige PAX5 Proteine) DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination.
Data show that loss of PTIP resulting in subtle changes in gene expression patterns and lower H3K4 methylation.
PTIP accumulation at double stranded breaks contributes to class switch recombination and genome stability independently of Igh switch transcription
PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.
PAX transcription activation domain interacting protein 1 like
, PAX-interacting protein 1
, protein encoded by CAG trinucleotide repeats
, PAX transactivation activation domain-interacting protein
, SMAD wing for transcriptional activation
, protein Swift
, PAX interacting protein 1