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anti-Mouse (Murine) MUC4 Antikörper:
anti-Human MUC4 Antikörper:
anti-Rat (Rattus) MUC4 Antikörper:
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Human Monoclonal MUC4 Primary Antibody für IHC (p), ELISA - ABIN561876
Smalley, Sheman, Nelson, Theodorescu: Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. in Journal of proteome research 2008
Show all 4 Pubmed References
Human Polyclonal MUC4 Primary Antibody für ICC, IF - ABIN4336444
Milara, Morell, Ballester, Armengot, Morcillo, Cortijo: MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps. in The Journal of allergy and clinical immunology 2016
the role of Muc4 in driving intestinal inflammation and inflammation-associated tumorigenesis
Results show that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin (zeige SLC13A2 Antikörper) in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients.
Using the Pdx1 (zeige PDX1 Antikörper)-Cre; LStopL-K-rasG12D mouse model of pancreatic carcinogenesis, in vivo early Muc4 neo-expression of in pancreatic intraepithelial neoplastic lesions induced by mutated hK-ras is correlated with the ERK (zeige EPHB2 Antikörper), JNK (zeige MAPK8 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) signaling pathways.
Data show that Muc4 is upregulated and interacts with erbB2 (zeige ERBB2 Antikörper) in gallbladders from BK5.erbB2 (zeige ERBB2 Antikörper) mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 (zeige ERBB2 Antikörper) signaling.
This study delineates the association and the downstream mechanisms of MUC4-regulated elevation of lipocalin-2 (zeige LCN2 Antikörper) and its clinical significance for prognosis of pancreatic cancer.
MUC4-NIDO domain significantly contributes to the MUC4-mediated metastasis of PC cells
ErbB2 (zeige ERBB2 Antikörper) and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells
As a luminal surface component, the MUC4 is situated to contribute to the non-adhesive luminal surface and to act as an intrinsic protection and survival factor for blood vessels
MUC4 is regulated at the transcriptional level by CDX-1 (zeige CDX1 Antikörper) and -2, HNF-1 alpha (zeige HNF1A Antikörper) and -1 beta, FOXA1 (zeige FOXA1 Antikörper)/A2, HNF-4 alpha (zeige HNF4A Antikörper) and -4 gamma, and GATA-4 (zeige GATA4 Antikörper), -5, and -6 factors in a cell-specific manner
the expression of mucins 1 to 4 and trefoil factor 3 (zeige TFF3 Antikörper) was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
TNFalpha (zeige TNF Antikörper) induced upregulation of MUC4 that reduced trastuzumab binding to its epitope and impaired ADCC. Silencing MUC4 enhanced trastuzumab binding, increased ADCC, and overcame trastuzumab and trastuzumab-emtansine antiproliferative effects in TNFalpha (zeige TNF Antikörper)-overexpressing cells. In HER2 (zeige ERBB2 Antikörper)-positive breast cancer samples, MUC4 expression was found to be an independent predictor of poor disease-free survival.
MUC4 is a novel and useful negative immunohistochemical marker for differentiating sarcomatoid mesothelioma from lung sarcomatoid carcinoma
NIDO, AMOP and vWD (zeige VWF Antikörper) domains of MUC4 play synergic roles in MUC4 mediated signaling in pancreatic cancer cells.
MUC1 and MUC4 expression are increased by hypoxia and DNA hypomethylation; this status is statistically associated with development of distant metastasis, tumor stage and overall survival for pancreatic ductal adenocarcinoma (stage IIA and IIB) patients
Study provides evidence that AMOP domain plays the key role in MUC4-mediated tumor angiogenesis and metastasis of pancreatic cancer cells partly through the NOTCH3 (zeige NOTCH3 Antikörper) signaling and its downstream target genes: VEGF-A (zeige VEGFA Antikörper), MMP-9 (zeige MMP9 Antikörper) and ANG-2 (zeige ANGPT2 Antikörper).
elevated levels of bile acid increase the tumorigenic potential of pancreatic cancer cells by inducing FXR (zeige NR1H4 Antikörper)/FAK (zeige PTK2 Antikörper)/c-Jun (zeige JUN Antikörper) axis to upregulate MUC4 expression.
High MUC4 expression is associated with CRLF2 (zeige CRLF2 Antikörper)-rearranged acute lymphoblastic leukemia.
Low expression of MUC4 was associated with favorable survival, whereas high MUC4 expression did not correlate with survival in resectable pancreatic cancer patients receiving adjuvant gemcitabine treatment.
the present study provides evidence that hypoxia negatively regulates MUC4 expression in PC by affecting its stability.
Studies indicate that a positive or high expression level of mucin 4 (MUC4) was significantly related to poor survival in patients with resected cholangiocarcinoma (CC).
Polymorphism of FUT1 (zeige FUT1 Antikörper) and MUC4 associated with resistance to colibacteriosis was determined.
Haplotype phylogeny analyses indicated that MUC4 had evolved divergently in Chinese and Western pigs.
A SNP in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify ETEC susceptible pigs.
data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
, mucin 4, ASGP
, pancreatic adenocarcinoma mucin
, testis mucin
, mucin 4, tracheobronchial
, tracheobronchial mucin
, pre-sialomucin complex
, sialomucin ascites sialoglycoprotein-1
, sialomucin complex