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anti-Human IL27 Receptor alpha Antikörper:
anti-Mouse (Murine) IL27 Receptor alpha Antikörper:
anti-Rat (Rattus) IL27 Receptor alpha Antikörper:
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Human Monoclonal IL27 Receptor alpha Primary Antibody für FACS - ABIN4897457
Kachroo, Lee, Zhang, Baratelli, Lee, Srivastava, Wang, Walser, Krysan, Sharma, Dubinett, Lee: IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. in Journal of experimental & clinical cancer research : CR 2013
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Human Polyclonal IL27 Receptor alpha Primary Antibody für IHC, ELISA - ABIN1003239
Sprecher, Grant, Baumgartner, Presnell, Schrader, Yamagiwa, Whitmore, OHara, Foster: Cloning and characterization of a novel class I cytokine receptor. in Biochemical and biophysical research communications 1998
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Human Polyclonal IL27 Receptor alpha Primary Antibody für IHC, ELISA - ABIN1003238
Chen, Ghilardi, Wang, Baker, Xie, Gurney, Grewal, de Sauvage: Development of Th1-type immune responses requires the type I cytokine receptor TCCR. in Nature 2000
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Mouse (Murine) Monoclonal IL27 Receptor alpha Primary Antibody für CyTOF, FACS - ABIN4900137
Pradhan, Lambert, Reuther: Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Human Polyclonal IL27 Receptor alpha Primary Antibody für IF (p), IHC (p) - ABIN749498
Xu, Yi, Wang, Hu, Han, Xue, Zhang, Luan: IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations. in Immunologic research 2017
Mouse (Murine) Monoclonal IL27 Receptor alpha Primary Antibody für FACS - ABIN5666540
Mascanfroni, Yeste, Vieira, Burns, Patel, Sloma, Wu, Mayo, Ben-Hamo, Efroni, Kuchroo, Robson, Quintana: IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. in Nature immunology 2013
this study found elevated expression of IL-27 (zeige IL27 Antikörper) in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth
These results identify IL-27 (zeige IL27 Antikörper) and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
Findings demonstrated that IL-27 (zeige IL27 Antikörper) and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 (zeige IL27 Antikörper) can modulate immune properties of astrocytes and infiltrating immune cells
The significant expression of IL-27 (zeige IL27 Antikörper) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (zeige EBI3 Antikörper) pair is detrimental in TB.
natural sIL (zeige PMEL Antikörper)-27Ralpha binds rIL (zeige PDLIM4 Antikörper)-27, inhibits IL-27 (zeige IL27 Antikörper) binding to its cell surface receptor, and is a potent inhibitor of IL-27 (zeige IL27 Antikörper) signaling, as shown by its ability to specifically block IL-27 (zeige IL27 Antikörper)-mediated STAT (zeige STAT1 Antikörper) activation, at low molar excess over IL-27 (zeige IL27 Antikörper).
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes.
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration.
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.
WSX-1 is essential for transcriptional activation of STAT1 (zeige STAT1 Antikörper) and for augmenting the induction of T-bet expression during initiation of Th1 (zeige TH1L Antikörper) cell differentiation.
WSX-1 together with the cytokine receptor (zeige EBI3 Antikörper) gp130 (zeige IL6ST Antikörper) constitutes a functional signal-transducing receptor for IL-27 (zeige IL27 Antikörper).
Study reports a high-incidence, low-variation spontaneous mouse model of spondyloarthropathy that delineates how the combination of inflammatory cytokine interleukin-27 (IL-27 (zeige IL27 Antikörper)) signaling deficiency and mitogenic signaling (mutant p53R172H) in vivo, leads to bone loss in the vertebral bodies and ossification of the cartilage in the intervertebral discs.
IL-27 (zeige IL27 Antikörper) signaling in Foxp3 (zeige FOXP3 Antikörper)(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system
The combination of mutant p53 (zeige TP53 Antikörper) & IL27RA(-/-) causes spontaneous liver inflammation, steatosis, and fibrosis, whereas either gene alone has no effects on the liver.
IL-10 (zeige IL10 Antikörper) production by CD4 (zeige CD4 Antikörper)(+) YFP(+) T cells is controlled systemically during malaria infection through IL-27 (zeige IL27 Antikörper) receptor signaling that is supported after CD4 (zeige CD4 Antikörper)(+) T cell priming by ICOS (zeige ICOS Antikörper) signaling.
The significant expression of IL-27 (zeige IL27 Antikörper) in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor (zeige LEPR Antikörper) pair is detrimental in TB.
IL-27R-mediated regulation of IL-17 (zeige IL17A Antikörper) controls the development of respiratory syncytial virus-associated pathogenesis.
CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice
The loss of IL-27R signaling across the whole mouse resulted in reduced viral control and a slight increase in the number of virus-specific CD4 (zeige CD4 Antikörper) T cells at early stages of viral infection.
Diminution of the Th1 response in infected Il27ra mice in vivo by neutralization of IL-12p40 attenuated CCR5 expression.
These findings establish a novel antiatherogenic role for IL-27 (zeige IL27 Antikörper) receptor signaling, which acts to suppress the production of proinflammatory cytokines and chemokines and to curb the recruitment of inflammatory myeloid cells into atherosclerotic aortas.
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.
interleukin 27 receptor, alpha
, class I cytokine receptor
, interleukin-27 receptor subunit alpha
, type-I T cell cytokine receptor
, IL-27 receptor subunit alpha
, IL-27R subunit alpha
, T-cell cytokine receptor type 1
, cytokine receptor WSX-1
, cytokine receptor-like 1
, type I T-cell cytokine receptor
, T cell cytokine receptor
, T cell cytokine receptor; cytokine receptor family, class 1 (WSXWS), member 1
, cytokine receptor family, class 1 (WSXWS), member 1