HLA-A Proteine (HLA-A)

Bezeichnung:
Major Histocompatibility Complex, Class I, A Proteine (HLA-A)
Auf www.antikoerper-online.de finden Sie aktuell 44 Major Histocompatibility Complex, Class I, A (HLA-A) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HLA-A Antikörper (173) und HLA-A Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 228 HLA-A Produkte verfügbar.
Synonyme:
HLAA
alle Proteine anzeigen Gen GeneID UniProt
HLA-A 3105 P30443 , P04439
HLA-A    

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Human Major Histocompatibility Complex, Class I, A (HLA-A) Interaktionspartner

  1. Data suggest that only a small fraction of HLA-A*02:01- (HA)-binding ESO peptides are immunogenic, namely those that have high peptide-binding strength and peptide/HA complex stability. This study involved comparison of in silico-predicted and observed cytotoxic T-lymphocyte recognition of tumor antigen epitopes in melanoma patients and transgenic/knockout mice. (ESO = tumor antigen NY-ESO-1 (zeige CTAG1B Proteine))

  2. The safety, the overall survival (OS), and the immunological responses based on an ELISPOT assay were determined to assess differences in patients who were HLA-A24 (zeige CD164 Proteine)-positive [24(+)] and HLA-A24 (zeige CD164 Proteine)-negative [24(-)].

  3. Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. The common alleles of human populations comprise 42 core alleles, which represent all selected polymorphism, and recombinants that have assorted this polymorphism

  4. It was shown that the HLA-A*34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A*24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with recurrent spontaneous abortion

  5. HLA-A alleles were not associated with predisposition to cutaneous leishmaniasis.

  6. a significant level of epitope-specific T cells could be detected ex vivo in peripheral blood mononuclear cells from active TB patients by an HLA-A*11:01 dextramer carrying the peptide Rv3130c194-204.

  7. In conclusion, our results confirm that the alleles HLA-A*02 and HLA-DRB1 (zeige HLA-DRB1 Proteine)*07 are associated with the pathogenesis of vitiligo (zeige MITF Proteine) in the Brazilian population. We demonstrated that allele HLA-A*32 is associated with susceptibility to localized vitiligo (zeige MITF Proteine).

  8. HLA-A*24:02 is a common genetic risk factor for cutaneous adverse reactions induced by aromatic antiepileptic drugs in the southern Han Chinese and possibly other ethnic populations.

  9. the results support that a regulated assembly of these noncanonical HLA-I conformers during the immune response may enhance the avidity of their interaction with LILRB1 (zeige LILRB1 Proteine).

  10. HLA-A*33:01 was associated with drug induced liver injury due to terbinafine and possibly fenofibrate and ticlopidine.

HLA-A Protein Überblick

Protein Überblick

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

Alternative names and synonyms associated with HLA-A

  • major histocompatibility complex, class I, A (HLA-A)
  • HLAA Protein

Bezeichner auf Proteinebene für HLA-A

HLA class I histocompatibility antigen, A-1 alpha chain , MHC class I antigen HLA-A heavy chain , antigen presenting molecule , leukocyte antigen class I-A

GENE ID SPEZIES
3105 Homo sapiens
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