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Human Polyclonal PPP1R9B Primary Antibody für ELISA, WB - ABIN566586
Sagara, Kawasaki, Iemura, Natsume, Takai, Akiyama: Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. in Oncogene 2009
Study determined that spinophilin binding to neurofilament medium required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5.
Clinical onset of AD is marked by the loss of PreC spinophilin-ir dendritic spines that is related to Abeta pathology and may contribute to cognitive symptoms early in the disease.
The increased cancer stem cells-like properties induced by the downregulation of Spn might account for the increased malignant phenotype observed in Spn-null breast tumors.
homo-oligomerization of neurabin is required for stabilizing RGS4 on the plasma membrane to attenuate A1R signaling
Data identify Spn as a critical adhesion and signaling protein that is essential for modulating glioblastoma cell invasion in the brain microenvironment. Spn suppresses brain tumor cell invasion, in part, via control of Rac1 GTPase activities and invadopodia disassembly. Its C-terminus binds directly to the beta 8 integrin cytoplasmic tail.
results indicate that spinophilin plays an important role in regulating the activity of Group I mGluRs as well as their influence on synaptic activity.
Low spinophilin expression enhances aggressive biological behavior of breast cancer.
Colorectal carcinoma expression of spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance.
spinophilin might play a previously unrecognized role in the pathogenesis of head and neck squamous cell carcinoma
Spn downregulation contributes to a more aggressive biologic behavior, induces chemoresistance, and is associated with a poorer survival in patients with advanced stages of colorectal carcinoma.
study found a substantial number of hepatocellular carcinomas (HCC) show reduced or absent Spn expression; the low expression of Spn in tumour tissue is an independent negative prognostic factor for clinical outcome in HCC; spinophilin expression inversely correlates with proliferative activity
Studies suggest that any change in substrate specificity of the spinophilin : PP1 holoenzyme complex was probably due to direct modification of a PP1 substrate binding surface.
Spinophilin associates with both delta- and mu-OmicronR and G protein subunits in HEK293 cells participating in a multimeric signaling complex that displays a differential regulatory role in opioid receptor signaling.
Spinophilin-deficient mice have enhanced antidepressant response to desipramine compared with wild-type controls.
Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
The molecular size and subcellular location of myotube glycogen particles is determined by the PPP1R6, PTG and G(M) scaffolding.
IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1
The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines.
Decreased spinophilin but unchanged MAP2 expression provides molecular evidence for a hippocampal dendritic pathology in schizophrenia that preferentially affects the spines.
PPP1R9B is required for synapse formation in the NK cells and suggest that it may be involved in the maintenance of cellular architecture by regulation of actin assembly, possibly acting to stabilize the NKIS until granule release is eminent.
spinophilin fulfills an essential role in cocaine-induced behavioral sensitization, likely via ERK1/2 phosphorylation and induction of c-Fos and FosB in the striatum.
two homologs neurabin and spinophilin play important yet distinct roles in the regulation of anxiety- and depression-like behaviors in an age-dependent manner.
COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0.05), leading to significant deficits in learning and memory skills
RanBP9 overexpression in transgenic mice led to striking reduction in the levels of spinophilin.
Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR endocytic responses.
Findings support the concept that the inhibitory effects of SPL on M3R activity are mediated by RGS4.
changes in spinophilin/CaMKII interactomes may contribute to changes in striatal dendritic spine density, morphology, and function during normal postnatal maturation and aging.
these data suggest that spinophilin is an upstream regulator required for normal growth and excitation-contraction coupling, but is dispensable for beta-adrenergic stimulation of adult cardiomyocytes.
Findings suggest that spinophilin restrains Angiotensin II-mediated sympathetic nervous system activation and is an unrecognized molecule with regard to central blood pressure control
We suggest that Spn may be the tumor suppressor gene located at 17q21.33 acting through Rb regulation.
the combined loss of Spn and mutant p53 activity led to increased mammary carcinomas, confirming the functional relationship between p53 and Spn.
role in stabilizing cell surface expression of alpha 2B-adrenergic receptors
The coiled-coil domain of neurabin II binds to a DCX region encompassing the C-terminal portion of the second DCX repeat and the N-terminal portion of the Ser/Pro-rich domain.
by blocking G protein receptor kinase 2 association with receptor-Gbetagamma complexes, spinophilin reduces arrestin- stabilized receptor phosphorylation, receptor endocytosis & acceleration of mitogen-activated protein kinase activity after endocytosis
Dcx acts as a molecular link between microtubule and actin cytoskeletal filaments that is regulated by phosphorylation and neurabin II.
protein kinase A-dependent phosphorylation of spinophilin at Ser94 in both striatonigral and striatopallidal neurons requires synergistic contributions from the protein kinase A and DARPP-32/protein phosphatase-1 pathways
These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response.
Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors.
Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1\; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997
, neurabin 2
, neural tissue-specific F-actin-binding protein II
, nuerabin 2
, neurabin II
, protein phosphatase 1, regulatory (inhibitor) subunit 9B
, protein phosphatase 1, regulatory subunit 9B, spinophilin