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anti-Mouse (Murine) GUCA1B Antikörper:
anti-Human GUCA1B Antikörper:
anti-Cow (Bovine) GUCA1B Antikörper:
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Cow (Bovine) Polyclonal GUCA1B Primary Antibody für WB - ABIN611262 : Chen, Chédotal, He, Goodman, Tessier-Lavigne: Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. in Neuron 1997 (PubMed) Show all 3 Pubmed References
Human Polyclonal GUCA1B Primary Antibody für WB - ABIN1881399 : Sato, Nakazawa, Usui, Tanimoto, Abe, Ohguro: Mutations in the gene coding for guanylate cyclase-activating protein 2 (GUCA1B gene) in patients with autosomal dominant retinal dystrophies. in Graefe's archive for clinical and experimental ophthalmology 2005 (PubMed) Show all 3 Pubmed References
The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1.
This study identifies a new mechanism governing GCAP2 (zeige GUCA2B Antikörper) subcellular distribution in vivo, closely related to disease.
Overexpression of guanylate cyclase activating protein 2 in rod photoreceptors in vivo leads to morphological changes at the synaptic ribbon.
GCAP (zeige GUCA1A Antikörper)-activated native retinal membrane (Ret (zeige RET Antikörper))GC1 and RetGC2 (zeige GUCY2F Antikörper) are less sensitive to inhibition by calcium ions in the presence of GCAP1 (zeige GUCA1A Antikörper) than GCAP2 (zeige GUCA2B Antikörper).
GCAP2 (zeige GUCA2B Antikörper) is a prime candidate for mediating Ca2 (zeige CA2 Antikörper)+-dependent dynamic changes of synaptic ribbons in photoreceptor synapses
GCAP (zeige GUCA1A Antikörper) functions in intact photoreceptors [review]
GCAP2 (zeige GUCA2B Antikörper) regulation of guanylyl cyclase activity quickens the recovery of flash and step responses and adjusts the operating range of rods to higher intensities of ambient illumination
Prolonged illumination up-regulates retinal arrestin (zeige SAG Antikörper) and Guca1a (zeige GUCA1A Antikörper)/b: a novel mechanism for light adaptation.
Mapping Calcium-Sensitive Regions in the Neuronal Calcium Sensor GCAP2 by Site-Specific Fluorescence Labeling.
The C-terminal segment in GCAP2 confers target selectivity, facilitates membrane binding and provides sensitivity of the membrane localization of the protein to phosphorylation by rhodopsin kinase (zeige GRK1 Antikörper).
Based on the distance constraints imposed by the cross-links, the study derived a 3D-structural model of the GCAP2 homodimer.
Data suggest that dimerization domain of GUCY2D (zeige GUCY2D Antikörper) operates as a calcium-sensitive regulatory module; GUCY2D (zeige GUCY2D Antikörper) requires correct conformation of monomer-monomer interface for interaction with guanylate cyclase activating proteins (GCAP1 (zeige GUCA1A Antikörper); GCAP2).
interaction between N-terminally myristoylated GCAP-2 and a peptide derived from the catalytic domain of full-length ROS-GC 1
Ca2 (zeige CA2 Antikörper)+ exerted a stabilizing effect on both myristoylated and non-myristoylated forms of the protein, which was significantly stronger for myristoylated GCAP2.
GCAP2 is a prime candidate for mediating Ca2 (zeige CA2 Antikörper)+-dependent dynamic changes of synaptic ribbons in photoreceptor synapses
Findings show that the sequence motif of the core GCAP2-modulatory site is Tyr965-Asn981 of rod outer segment membrane guanylate cyclase (zeige GUCY2D Antikörper) type 1 (ROS-GC1); this site is absolutely specific for GCAP2 and does not overlap with the GCAP1 (zeige GUCA1A Antikörper)-modulated site.
Our data indicate that the Ca(2 (zeige CA2 Antikörper)+)-sensitivity of GCAP2 is significantly controlled by its third Ca(2 (zeige CA2 Antikörper)+)-binding site, EF-hand 3.
Dimerization domain of RETGC1 (zeige GUCY2D Antikörper) is an essential part of GCAP1 (zeige GUCA1A Antikörper) and GCAP2 binding interface.
The absence of clearly pathogenic mutations in the selected patient group suggests that the GUCA1B gene is a minor cause for retinal degenerations in Europeans or North-Americans.
Mutation in the GCAP 2 gene can cause one form of autosomal dominant retinal dystrophy (zeige MERTK Antikörper), with variable phenotypic expression and incomplete penetrance.
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.
guanylate cyclase activator 1B (retina) , GCAP 2 , GCAP2 (retina) , guanylyl cyclase-activating protein 2 , retinal guanylyl cyclase activator protein p24 , guanylate cyclase-activating protein, photoreceptor 2 , calcium binding protein , guanylate cyclase activating protein 2