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The expression level of DYRK2 was positively correlated with glioma pathological grade.
Results provide evidence that DYRK2 suppresses the proliferation of breast cancer cells and invasion through CDK14 (zeige CDK14 Proteine) expression.
Study found that DYRK2 regulates liver metastases of colorectal cancer cells through the activation of EMT (zeige ITK Proteine), and that patients with low DYRK2-expressing colorectal cancer liver metastases had worse outcomes than those with high DYRK2-expressing metastases.
our results delineate a novel mechanism of cancer stem cell regulation by the DYRK2-AR-KLF4 (zeige KLF4 Proteine) axis. Restoration of the expression and function of DYRK2 is a potential therapeutic strategy against breast cancer stem cells.
lower DYRK2 levels were correlated with tumor sites, advanced clinical stages, and shorter survival in the advanced clinical stages. DYRK2 is a novel prognostic biomarker of human colorectal cancer.
Diminished DYRK2 expression sensitizes hormone receptor (zeige NR4A1 Proteine)-positive breast cancer to everolimus by preventing mTOR (zeige FRAP1 Proteine) degradation.
Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage.
the downregulated expression of DYRK2 in HCC (zeige FAM126A Proteine) tumor tissues could promote the proliferation of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cells. In addition, reducing DYRK2 expression was associated with poor prognosis and Oxaliplatin resistance in HCC (zeige FAM126A Proteine).
Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma
DYRK2 may regulate EMT (zeige ITK Proteine) through Snail (zeige SNAI1 Proteine) degradation in ovarian SA and might be a predictive marker for a favorable prognosis in the treatment of this cancer.
data indicate that DYRK2 is expressed in the developing muscle progenitor cells in somites and that it positively regulates fast-twitch muscle differentiation, at least at the early stages
These results suggest that the phosphorylation of Dpysl2 (zeige DPYSL2 Proteine) and Dpysl3 (zeige DPYSL3 Proteine) by Cdk5 (zeige CDK5 Proteine) and DYRK2 is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.
Dyrk2 regulates osteoclast fusion in a cell heterotypic manner.
DYRK2 regulates tumor progression through modulation of c-Jun (zeige JUN Proteine) and c-Myc (zeige MYC Proteine)
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
, dual specificity tyrosine-phosphorylation-regulated kinase 2