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Human Radixin Protein expressed in HEK-293 Cells - ABIN2730421
Miyaji, Shahrizaila, Umapathi, Chan, Hirata, Yuki: Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies? in Human immunology 2015
CPI-17 (zeige PPP1R14A Proteine) drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin (zeige NF2 Proteine) and activation of the growth promoting ERM (zeige ETV5 Proteine) family.
Radixin knockdown suppresses the metastasis of SGC (zeige SGCB Proteine)-7901 cells in vitro by up-regulation of E-cadherin (zeige CDH1 Proteine). The NF-kappaB (zeige NFKB1 Proteine)/snail (zeige SNAI1 Proteine) pathway contributes to the regulation of E-cadherin (zeige CDH1 Proteine) in response to depletion of radixin.
Phospho-Ezrin/Radixin/Moesin (ERM (zeige MSN Proteine)) inhibit cell adhesion, and therefore, dephosphorylation of ERM (zeige ETV5 Proteine) proteins is essential for cell adhesion.Phospho-ERM (zeige ETV5 Proteine) induce formation and/or maintenance of spherical cell shape.
These studies identify Akt2 (zeige AKT2 Proteine) as a critical kinase that regulates radixin phosphorylation and leads to Mrp-2 (zeige ABCC2 Proteine) translocation and function.
Intracellular sphingosine kinase 2 (zeige SPHK2 Proteine)-derived sphingosine-1-phosphate mediates epidermal growth factor (zeige EGF Proteine)-induced ezrin-radixin-moesin (zeige MSN Proteine) phosphorylation and cancer cell invasion.
High Radixin expression is associated with glioblastoma.
Ezrin (zeige EZR Proteine), radixin and moesin (zeige MSN Proteine) are unlikely targets for autoantibodies in demyelinating neuropathies.
Data show that silencing ezrin-radixin-moesin (ERM (zeige MSN Proteine)) protein expression ablates deleted in colorectal carcinoma (zeige DCC Proteine) protein (DCC (zeige DCC Proteine))-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation.
These data suggest an association between RDX polymorphisms and the clinical features of RA patients, particularly the ESR (zeige ESR1 Proteine)
Radixin was identified as a target gene of miR (zeige MLXIP Proteine)-196a/-196b. Elevated miR (zeige MLXIP Proteine)-196a/-196b expression in GC cells led to reduced radixin protein levels and vice versa.
LRBA (zeige LRBA Proteine) deficiency is associated with a reduced abundance of radixin and Nherf2 (zeige SLC9A3R2 Proteine), two adaptor proteins, which are important for the mechanical stability of the basal taper region of stereocilia.
Inactivation of SHIP2 (zeige INPPL1 Proteine) leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin (zeige MSN Proteine) proteins and increased Rho-GTP (zeige AK3 Proteine).
identification of radixin as a PRG-2 (zeige PTGR2 Proteine) interaction partner and showing that radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG-2 (zeige PTGR2 Proteine)
These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane.
The specific location of radixin-positive cells in the peri (zeige POSTN Proteine)-infarct region and in microglia suggests a role for radixin in microglial activation after stroke.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
the extracellular matrix molecule VN and its neuronal receptor TLCN (zeige ICAM5 Proteine) play a pivotal role in the phosphorylation of ezrin/radixin/moesin (zeige MSN Proteine) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
Ezrin/radixin/moesin (zeige MSN Proteine) are required for the purinergic P2X7 receptor (P2X7R (zeige P2RX7 Proteine))-dependent processing of the amyloid precursor protein (zeige APP Proteine).
The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers.
Ezrin-radixin-moesin (ERM (zeige MSN Proteine)) proteins are induced in activated microglia/macrophages, whereas ERM (zeige ETV5 Proteine) molecules are only marginally expressed in quiescent microglia in the normal brain.
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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