anti-Discs, Large Homolog 1 (Drosophila) (DLG1) Antikörper

Mouse (Murine) Discs, Large Homolog 1 (Drosophila) (DLG1) Interaktionspartner

1. we found that Dlg1 was expressed at different stages of oocyte development. at the germinal vesicle stage, Dlg1 was present in the cytoplasm, prominently surrounding the germinal vesicle membrane. During maturation, Dlg1 became highly polarised by associating with the spindle and formed characteristic crescent (zeige SFRP5 Antikörper)-shaped accumulations under the cortex.

2. Adrenergic modulation of Kv1.1 (zeige KCNA2 Antikörper) was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 (zeige KCNA2 Antikörper) from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses.

3. that Pten, through the Dlg1-binding ability of its PDZ (zeige INADL Antikörper)-binding domain , accumulates phosphorylated Eg5 (zeige KIF11 Antikörper) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes

4. Kif13b (zeige KIF13B Antikörper) also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT (zeige AKT1 Antikörper) activation and promotes myelination

5. Dlg1 regulates p38 (zeige CRK Antikörper)-dependent proinflammatory cytokine production.

6. phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements

7. Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.

8. data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII (zeige CAMK2G Antikörper) activation.

9. Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.

10. lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux

Human Discs, Large Homolog 1 (Drosophila) (DLG1) Interaktionspartner

1. the increased expression of DLG1 may be predictive of an unfavorable prognosis in colorectal cancer.

2. By fluorescence resonance energy transfer (FRET), we detected the direct binding of Tax (zeige CNTN2 Antikörper) to DLG1 within the cell. The interaction specifically affects the cellular distribution of not only DLG1, but also Tax (zeige CNTN2 Antikörper). The aggregates distribute into the Golgi apparatus in spatial association with the microtubule-organizing center (MTOC).

3. These data support diverging presynaptic and postsynaptic roles of SAP97 N-terminal isoforms in synapse maturation and plasticity

4. Single nucleotide polymorphism in DLG1 gene is associated with schizophrenia.

5. Low expression of DLG1 is associated with Crohn's disease.

6. BAIAP2 (zeige BAIAP2 Antikörper) is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (zeige HELLS Antikörper) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.

7. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.

8. that Pten, through the Dlg1-binding ability of its PDZ (zeige INADL Antikörper)-binding domain , accumulates phosphorylated Eg5 (zeige KIF11 Antikörper) at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes

9. Results suggest that discs large (zeige DLG4 Antikörper) tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.

10. Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.