anti-Discs, Large Homolog 1 (Drosophila) (DLG1) Antikörper

Mouse (Murine) Discs, Large Homolog 1 (Drosophila) (DLG1) Interaktionspartner

1. Subjecting SAP97-cKO mice to a battery of behavioral tests revealed a subtle male-specific cognitive deficit and female-specific motor deficit, while other behaviors were largely unaffected. These data suggest that loss of SAP97 may have a modest contribution to organismal behavior.

2. we found that Dlg1 was expressed at different stages of oocyte development. at the germinal vesicle stage, Dlg1 was present in the cytoplasm, prominently surrounding the germinal vesicle membrane. During maturation, Dlg1 became highly polarised by associating with the spindle and formed characteristic crescent-shaped accumulations under the cortex.

3. Adrenergic modulation of Kv1.1 was mediated by the signaling scaffold SAP97, which, through direct protein-protein interactions, escorts beta2 signaling to remove Kv1.1 from the dendrite surface. This process promoted spike timing-dependent long-term synaptic potentiation at mouse hippocampal excitatory synapses.

4. that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes

5. Kif13b also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT activation and promotes myelination

6. Dlg1 regulates p38-dependent proinflammatory cytokine production.

7. phenotypes of Dlg1-/- mice involving cellular disorganization and insufficient tissue elongation strongly suggest a defect in the convergent extension movements

8. Loss of Dlg1 confers strong predisposition to the development of pediatric B-ALL in a murine model.

9. data indicate that the surface expression and function of EAAT2b can be rapidly modulated through the disruption of its interaction with DLG1 by CaMKII activation.

10. Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.

11. lack of the Dlg1 gene induces a decrease in apoptotic epithelial cell death and the persistence of the common nephric duct, which result in a dysfunctional vesicoureteral junction and cause megaureter or hydronephrosis through vesicoureteral reflux

12. DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis.

13. Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex in mice.

14. DLG1 and CASK play critical cooperative roles in maintaining the nephron progenitor population, potentially via a mechanism involving effects on FGF signaling

15. studies show that SAP97 interactions with CRFR1 attenuate CRFR1 endocytosis and that SAP97 is involved in coupling G protein-coupled receptors to the activation of the ERK1/2 signaling pathway.

16. Mice in which SAP97, the mammalian homolog of DlgS97, was conditionally deleted in adults failed to develop rapid tolerance to ethanol's sedative/hypnotic effects.

17. These findings identify novel roles for Dlgh-1 in vertebrates that differ from its well-characterized roles in invertebrates and suggest that the Dlgh-1 null mouse may be a useful animal model to study certain human congenital birth defects.

18. Dlg1 regulates the generation of memory T cells.

19. T cells with acute Dlg1 suppression manifest differential requirements for Dlg1 activity in signaling events leading to Th1 versus Th2 cytokine induction.

20. SAP97 promotes the stability of Nax channels at the plasma membrane.

Human Discs, Large Homolog 1 (Drosophila) (DLG1) Interaktionspartner

1. Comparison with expanded cord blood-derived CD4(+)CD25(hi) tTreg and expanded Teffs from the same donors indicate that iTreg are intermediate between expanded CD4(+)CD25(hi) tTregs and Teffs, whereas modulation of suppressive activities by PKC-theta; and Dlgh1 signaling pathways are shared.

2. the increased expression of DLG1 may be predictive of an unfavorable prognosis in colorectal cancer.

3. By fluorescence resonance energy transfer (FRET), we detected the direct binding of Tax to DLG1 within the cell. The interaction specifically affects the cellular distribution of not only DLG1, but also Tax. The aggregates distribute into the Golgi apparatus in spatial association with the microtubule-organizing center (MTOC).

4. These data support diverging presynaptic and postsynaptic roles of SAP97 N-terminal isoforms in synapse maturation and plasticity

5. Single nucleotide polymorphism in DLG1 gene is associated with schizophrenia.

6. Low expression of DLG1 is associated with Crohn's disease.

7. BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.

8. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.

9. that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes

10. Results suggest that discs large tumour suppressor (DLG1) expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.

11. Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia was identified.

12. Human papillomavirus oncoproteins E6 and E7 induce the loss of DLG1 from the cell borders and an increase in the level of DLG1 protein, reflecting the pattern observed in cervical lesions.

13. The study provides new evidence for understanding the transcriptional regulation of DLG1 and the changes in DLG1 expression during different biological processes.

14. Trans-homophilic interaction of CADM1 activates PI3K by forming a complex with MAGuK-family proteins MPP3 and Dlg.

15. the synapse-associated protein-97 (SAP97), an excitatory synapse scaffolding element, governs ADAM10 trafficking from dendritic Golgi outposts to synaptic membranes, mediated by a previously uncharacterized protein kinase C.

16. E4-ORF1 interacts with Dlg1 and PI3K to assemble a ternary complex where E4-ORF1 hijacks the Dlg1 oncogenic function to relocate cytoplasmic PI3K to the membrane for constitutive activation.

17. While other domains of SAP97 were involved in forward trafficking of GluN1-3 out of the endoplasmic reticulum (ER), the SH3 domain was necessary and sufficient to block the ER retention.

18. DLG1, XIST, DDX3Y and RPS4Y1 genes can classify samples into different group clearly, and they are regarded as high confidence distinct gene biomarkers of Parkinson disease.

19. Novel genetic variants in the coding regions of DLG1 gene associated with susceptibility to Crohn's disease.

20. These findings indicate that most, if not all, human adenovirus E4-ORF1 proteins share a conserved molecular mechanism of PI3K activation via Dlg1 binding and confer a common capacity to promote oncogenic transformation.