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Aberrant DNA methylation (zeige HELLS Proteine) of ADD2 could be potential screening markers of colorectal cancer.
Study evaluated effects of ADD genetic variability on cognitive functions in a sample of patients with schizophrenia, known to show a wide and heterogeneous neuropsychological deficit and found that ADD2 C1797T polymorphism showed diffuse effects on almost every cognitive domain.
ADD2 and NCX1 (zeige SLC8A1 Proteine) variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis.
Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1 (zeige SELPLG Proteine)-mediated neutrophil rolling on P-selectin (zeige SELP Proteine).
chorein interacts with beta-adducin and beta-actin (zeige ACTB Proteine).
phosphorylation of beta-adducin by GSK3 promotes efficient neurite outgrowth in neurons.
ALPHA AND BETA ADDUCIN POLYMORPHISMS AFFECT DECLINE OF RENAL FUNCTION IN HUMAN IGA NEPHROPATHY.
there was significant heterogeneity between Slavic and Italian subjects in the phenotype-genotype relationships with beta-adducin
Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase (zeige ATP1A1 Proteine) activity, mu2 (zeige AP2M1 Proteine)-subunit hyperphosphorylation, and impaired Na+,K+-ATPase (zeige ATP1A1 Proteine) endocytosis.
Polymorphisms in the ADD2 and ADD3 (zeige ADD3 Proteine) genes taken alone were not associated with blood pressure and renin (zeige REN Proteine) activity
Sez6l2 (zeige SEZ6L2 Proteine) is one of the auxiliary subunits of the AMPA (zeige GRIA3 Proteine) receptor and acts as a scaffolding protein to link GluR1 (zeige GRIA1 Proteine) to ADD. Furthermore, Sez6l2 (zeige SEZ6L2 Proteine) overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 (zeige SEZ6L2 Proteine) modulates AMPA (zeige GRIA3 Proteine)-ADD signal transduction.
Darpp32 (zeige PPP1R1B Proteine) interaction with beta-adducin may be the molecular pathway by which environmental changes may rapidly alter responsiveness of striatal neurons involved in the reward system.
Calcium plays a role in regulating the expression and function of beta-adducin to sustain normal organization of the spectrin-based cytoskeleton and the differentiation properties in keratinocytes through the calmodulin/EGFR/cadherin signaling pathway.
study identified novel long-distance upstream non-canonical polyadenylation-regulatory elements that enhance or silence 3'end processing of the Add2 PAS4 (zeige CD36 Proteine)
mice lacking beta-Adducin fail to assemble new synapses upon enhanced plasticity and exhibit diminished long-term hippocampal memory upon environmental enrichment.
Analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC (zeige CACNA1C Proteine)) spectrin deficiency, resulting in markedly reduced RBC (zeige CACNA1C Proteine) membrane spectrin content, decreased band 3 (zeige SLC4A1 Proteine), and absent beta-adducin.
Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin, septin 2 (zeige SEPT2 Proteine), and sh3p8 (zeige SH3GL1 Proteine) as putative paranodal proteins.
beta-Adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.
Beta-adducin plays an essential role in the maintenance of erythrocyte shape and membrane stability.
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.
adducin 2 (beta)
, erythrocyte adducin subunit beta
, snoRNA MBII-396
, adducin beta