RECQL2 Produkte
(Werner syndrome RecQ like helicase (WRN))
Kategorien
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008].
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Ausgewählte RECQL2 Kategorien
RECQL2 Antikörper
High quality antibodies with extensive validation data.
Empfohlene RECQL2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, FACS, IHC (p)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN656017
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (4)
Kat. Nr.
ABIN521400
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, ICC, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN2854925
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene RECQL2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6222562
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene RECQL2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN1325380
Menge
2 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7125728
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3096338
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren RECQL2 Produkten
: "Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome." in: Internal medicine (Tokyo, Japan), Vol. 58, Issue 1, pp. 109-113, (2019) (PubMed).: "WRN helicase is a synthetic lethal target in microsatellite unstable cancers. ..." in: Nature, Vol. 568, Issue 7753, pp. 551-556, (2019) (PubMed).
: "miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment." in: Molecular carcinogenesis, Vol. 57, Issue 2, pp. 295-302, (2018) (PubMed).
: "CDK1 phosphorylates WRN at collapsed replication forks." in: Nature communications, Vol. 7, pp. 12880, (2016) (PubMed).
: "DNA2 drives processing and restart of reversed replication forks in human cells." in: The Journal of cell biology, Vol. 208, Issue 5, pp. 545-62, (2015) (PubMed).
: "WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome." in: Virchows Archiv : an international journal of pathology, Vol. 466, Issue 3, pp. 343-50, (2015) (PubMed).
: "The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa." in: Nucleic acids research, Vol. 42, Issue 19, pp. 12027-40, (2014) (PubMed).
: "Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress." in: Nucleic acids research, Vol. 42, Issue 20, pp. 12628-39, (2014) (PubMed).
: "Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling." in: DNA repair, Vol. 12, Issue 2, pp. 128-39, (2013) (PubMed).
: "Identification and characterization of SMARCAL1 protein complexes." in: PLoS ONE, Vol. 8, Issue 5, pp. e63149, (2013) (PubMed).
Synonyme und alternative Namen zu RECQL2
Werner syndrome RecQ like helicase (WRN), mediator of RNA polymerase II transcription subunit 34 (LOC9327212), Bloom syndrome RecQ like helicase (blm), Werner syndrome RecQ like helicase (Wrn), Werner syndrome, RecQ helicase-like L homeolog (wrn.L), AI846146, ffa-1, recq2, RECQ3, RECQL2, recql2, RECQL3, recql3, RGD1564788, xBLM, xwrnBezeichner auf Proteinebene für RECQL2
- DNA helicase, RecQ-like type 3
- Werner syndrome ATP-dependent helicase
- exonuclease WRN
- recQ protein-like 2
- RECQL2
- Werner syndrome ATP-dependent helicase homolog
- focus forming activity 1
- focus-forming activity 1
- Werner syndrome, RecQ helicase-like
- similar to Werner syndrome helicase homolog
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