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Raet1d Antikörper (PE)

Dieses Anti-Raet1d-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Raet1d in FACS. Geeignet für Maus.
Produktnummer ABIN2663873

Kurzübersicht für Raet1d Antikörper (PE) (ABIN2663873)

Target

Raet1d (Retinoic Acid Early Transcript delta (Raet1d))

Reaktivität

Maus

Wirt

Maus

Klonalität

Monoklonal

Konjugat

Dieser Raet1d Antikörper ist konjugiert mit PE

Applikation

Flow Cytometry (FACS)

Klon

Charlotte d1-23
  • Aufreinigung

    The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

    Isotyp

    IgG1
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.2 mg/mL

    Buffer

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Protect from prolonged exposure to light. Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target

    Raet1d (Retinoic Acid Early Transcript delta (Raet1d))

    Andere Bezeichnung

    RAE-1delta

    Hintergrund

    RAE-1δ is one of the five RAE-1 family, GPI-linked membrane protein consisting of alpha, beta, gamma, delta, and epsilon. They are strong homology within the family, related by 92 % -95 % sequence identity. They are distantly related to MHC class I proteins. RAE-1 proteins are abundantly expressed in fetal tissues, but not in normal adult tissue. They are constitutively expressed on some tumors and can be induced by retinoid acid. Its ligand NKG2D is found on NK cells, many transformed cell lines, and LPS-stimulated peritoneal macrophages. The interaction of NKG2D with RAE-1 transmits stimulatory signals to NK cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing. They are involved in the regulation of innate and immune cytotoxic responses to tumors, pathogen-infected cells, and autoimmune diseases.
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