anti-Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 8 (SLC9A8) Antikörper

Mouse (Murine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 8 (SLC9A8) Interaktionspartner

1. NHE8 deficiency resulted in increased Lgr5 expression in the colon.

2. These results indicate that NHE8 plays essential function in both retinal pigment epithelium (RPE) and photoreceptor cells. NHE8 dysfunction either in photoreceptor or RPE is sufficient to cause retinal degeneration in adult mice at any age.

3. work has uncovered a crucial role of NHE8 in acrosome biogenesis and suggests that some forms of human globozoospermia might be caused by a loss of function of this Na(+)/H(+) exchanger.

4. NHE8 may be involved in the establishment of intestinal mucosal integrity by regulating the functions of goblet and Paneth cells.

5. NHE8 function is necessary for the survival of photoreceptor cells and NHE8 is important for RPE cell polarity and function

6. The NHE8 protein is required in the RPE to maintain correct regulation of endosomal volume and/or pH which is essential for the cellular integrity and subsequent function of RPE

7. Suggest a novel role of NHE8 in male fertility through its effect on modifying luteinizing hormone receptor function.

8. Both NHE3 and NHE8 likely play a role in neonatal acidification.

9. Altered ocular surface function and reduced epithelial DRA expression in NHE8-/- mice suggest that the role of NHE8 in ocular surface tissue involve in tear production and ocular epithelial protection.

10. NHE3 is the predominant Na(+)/H(+) exchanger in adult mice. NHE8 may play a compensatory role in renal acidification and blood pressure regulation in NHE3(-/-) mice.

11. NHE8 is indirectly involved in gastric bicarbonate secretion and gastric mucosal protection

12. the role of NHE8 in the intestine involves both sodium absorption and bicarbonate secretion

13. intestinal NHE8 has a compensatory role in NHE2X3 DKO mice and this regulation is gender-dependent.

14. Has >50% identity to Drosophila melanogaster "NHE1,"; NHE8 is expressed in the proximal kidney tubule, where it may contribute to apical membrane ion transport

15. NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms.

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 8 (SLC9A8) Interaktionspartner

1. work has uncovered a crucial role of NHE8 in acrosome biogenesis and suggests that some forms of human globozoospermia might be caused by a loss of function of this Na(+)/H(+) exchanger.

2. NHE8 is expressed in goblet cells, and the inflammatory cytokine TNF-alpha downregulates NHE8 expression by a transcriptional mechanism.

3. Exonic mutations in NHE8 cannot account for congenital sodium diarrhea.

4. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane.

5. These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology.

6. EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription.

7. No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.

8. NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms.

9. Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity.