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anti-Mouse (Murine) alpha Actinin 4 Antikörper:
anti-Rat (Rattus) alpha Actinin 4 Antikörper:
anti-Human alpha Actinin 4 Antikörper:
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Cow (Bovine) Polyclonal alpha Actinin 4 Primary Antibody für IHC, WB - ABIN2775288
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
Show all 3 Pubmed References
Human Monoclonal alpha Actinin 4 Primary Antibody für ELISA, FACS - ABIN261463
Koo, Apte: Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. in The Journal of biological chemistry 2009
Human Monoclonal alpha Actinin 4 Primary Antibody für IF, IHC (p) - ABIN559759
Yamada, Yanamoto, Yoshida, Yoshitomi, Kawasaki, Mizuno, Nemoto: RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma. in International journal of oral and maxillofacial surgery 2010
Human Polyclonal alpha Actinin 4 Primary Antibody für ICC, IF - ABIN4279711
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Cow (Bovine) Polyclonal alpha Actinin 4 Primary Antibody für WB - ABIN2775289
Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ... in Genome research 2006
Show all 2 Pubmed References
Focal segmental glomerulosclerosis Actn4 mutation promotes podocyte detachment through maladaptation to periodic stretch.
ACTN4 is a transcriptional coactivator of NF-kappaB (zeige NFKB1 Antikörper).
UCHL1 (zeige UCHL1 Antikörper) upregulation in ACTN4-associated FSGS.
sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4.
the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum.
Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4.
anti-dsDNA Fab (zeige FANCB Antikörper) may enhance F-actin formation by the proprietary modification of alpha-actinin-4
Together, these results indicate that alpha-actinin (zeige ACTN1 Antikörper) and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS (zeige AR Antikörper).
Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion.
newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin (zeige NPHS1 Antikörper)-supported slit diaphragm complex.
These results demonstrate that both actinin (zeige ACTN1 Antikörper)-1 and actinin-4 participate in the assembly of F-actin at invadopodia. Additionally, actinin-4 may have a selective advantage in accelerating invadopodia-mediated invasion of carcinoma cells.
Gene amplification of ACTN4 was a significant independent risk factor for death in patients with stage I/II oral tongue cancer (hazard ratio 6.08, 95% confidence interval 1.66-22.27). Gene amplification of ACTN4 is a potential prognostic biomarker for overall survival in oral tongue cancer.
ACTN4 knockdown near-completely abrogates both radioresistance and epithelial-mesenchymal transition-associated changes in breast cancer cells.
Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
Suggest that ACTN4 as a potential predictive biomarker for efficacy of adjuvant chemotherapy in stage-IB/II patients with non-small cell lung cancer, by reflecting the metastatic potential of tumor cells.
High ACTN4 expression is associated with Lung Squamous Cell Carcinoma.
Our findings indicate that ACTN4 promotes EMT (zeige ITK Antikörper) and tumorigenesis by regulating Snail (zeige SNAI1 Antikörper) expression and the Akt (zeige AKT1 Antikörper) pathway in cervical cancer. We propose a novel mechanism for EMT (zeige ITK Antikörper) and tumorigenesis in cervical cancer.
Study found a functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis.
SERPINE1 (zeige SERPINE1 Antikörper), ANGPLT4, CCL20 (zeige CCL20 Antikörper), and SAA1 (zeige SAA1 Antikörper) as well as the NF-kappaB (zeige NFKB1 Antikörper) (p65 (zeige GORASP1 Antikörper)) binding sites on GR-transrepressed promoters such as IL-1beta (zeige IL1B Antikörper), IL-6 (zeige IL6 Antikörper), and IL-8 (zeige IL8 Antikörper) Taken together, our data establish ACTN4 as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.
Here, we report the identification of a novel, disease-causing ACTN4 mutation (p.G195D, de novo) in a sporadic case of childhood FSGS using next generation sequencing.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
actinin, alpha 4
, F-actin cross-linking protein
, non-muscle alpha-actinin 4
, alpha actinin 4
, actinin alpha4 isoform
, focal segmental glomerulosclerosis 1