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CXCL9 Protein

Dieses CXCL9-Protein wird in Escherichia coli (E. coli) produziert.
Produktnummer ABIN988151

Kurzübersicht für CXCL9 Protein (ABIN988151)

Target

Alle CXCL9 Proteine anzeigen
CXCL9 (gamma-Interferon-Induced Monokine (CXCL9))

Biologische Aktivität

Active

Spezies

  • 10
  • 7
  • 1
  • 1
Human

Quelle

  • 11
  • 4
  • 1
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 97 % by SDS-PAGE and HPLC analyses.
  • Sequenz

    TPVVRKGRCS CISTNQGTIH LQSLKDLKQF APSPSCEKIE IIATLKNGVQ TCLNPDSADV KELIKKWEKQ VSQKKKQKNG KKHQKKKVLK VRKSQRSRQK KT

    Produktmerkmale

    Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human peripheral blood T-lymphocytes is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.

    Endotoxin-Niveau

    Level Less than 1EU/µg of rHuMIG/CXCL9 as determined by LAL method
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

    Lagerung

    4 °C
  • Target

    CXCL9 (gamma-Interferon-Induced Monokine (CXCL9))

    Andere Bezeichnung

    MIG/CXCL9

    Hintergrund

    CXCL9, a member of the ª subfamily of chemokines that lack the ELR domain, was initially identified as a lymphokine-activated gene in mouse macrophages. The CXCL9 gene is induced in macrophages and in primary glial cells of the central nervous system specifically in response to IFN-γ. CXCL9 has been shown to be a chemoattractant for activated T-lymphocytes and TIL but not for neutrophils or monocytes. The human CXCL9 cDNA encodes a 125 amino acid residue precursor protein with a 22 amino acid residue signal peptide that is cleaved to yield a 103 amino acid residue mature protein. CXCL9 has an extended carboxy-terminus containing greater than 50% basic amino acid residues and is larger than most other chemokines. A chemokine receptor (CXCR3) specific for CXCL9 and IP-10 has recently been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes. Synonym: MIG/CXCL9, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 50mM NaCl.

    Molekulargewicht

    11.7 kDa, a single non-glycosylated polypeptide chain containing 103 amino acids.
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