CXCL5 Protein

Produktnummer ABIN988116

Produktdetails

Target: CXCL5 (Chemokine (C-X-C Motif) Ligand 5 (CXCL5))

Biologische Aktivität: Active

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Sequenz: APSSVIAATE LRCVCLTVTP KINPKLIANL EVIPAGPQCP TVEVIAKLKN QKEVCLDPEA PVIKKIIIQK ILGSDKKKAK RNALAVERTA SV

Produktmerkmale: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human peripheral blood neutrophils is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.

Reinheit: > 97 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: Level Less than 1EU/µg of rMuLIX/CXCL5 as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: CXCL5 (Chemokine (C-X-C Motif) Ligand 5 (CXCL5))

Andere Bezeichnung: LIX/CXCL5 (CXCL5 Produkte)

Hintergrund: The mouse homolog of ENA-78 is called LIX. ENA-78/LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78/LIX is a chemoattractant for neutrophils. The three naturally occurring variants of human ENA-78, ENA 5-78, ENA 9-78 and ENA 10-78, contain 74, 70, and 69 amino acid residues, respectively, and possess the same biological activity. ENA-78/LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the 'ELR' motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Synonym: LIX/CXCL5 (93a.a.), Mouse. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

Molekulargewicht: 9.8 kDa, a single, non-glycosylated polypeptide chain containing 93 amino acids.

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity