IL17F Protein

Produktnummer ABIN988050

Dieses IL17F-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für IL17F Protein (ABIN988050)

Target: IL17F (Interleukin 17F (IL17F))

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE and HPLC analyses.

Produktdetails

Sequenz: MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHV

Produktmerkmale: Fully biologically active when compared to standard. The ED50 determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 15 ng/ml, corresponding to a specific activity of >, 6.7 × 104 IU/mg.

Endotoxin-Niveau: Level Less than 1EU/µg of rHuIL-17F as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: IL17F (Interleukin 17F (IL17F))

Andere Bezeichnung: Interleukin-17F (IL-17F)

Hintergrund: Human IL-17F is synthesized as a 153 aa precursor with a 20 aa signal sequence and a 133 aa mature region. Like IL-17A, IL-17F contains one potential site for N-linked glycosylation. IL-17A and IL-17F share 50% aa sequence identity. IL17-F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17-F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Synonym: Interleukin-17F (IL-17F), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Molekulargewicht: A disulfide-linked homodimer of 30.1kDa, consisting of two 134 amino acid polypeptide chains.

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity