Exendin 4 Protein

Produktnummer ABIN987837

Dieses Recombinant Exendin 4-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Exendin 4 Protein (ABIN987837)

Target: Exendin 4

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Gila monster

Quelle: Escherichia coli (E. coli)

Reinheit: > 96 % by SDS-PAGE and HPLC analyses.

Produktdetails

Sequenz: HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPP

Produktmerkmale: 1. Regulates Glucose levels rapidly 2. Reduces Insulin resistence 3. Reduces Glucagon 4. Reduces HbA1c 5. Stimulates beta cell growth which stimulates insulin production.

Endotoxin-Niveau: Level Less than 10EU/mg of rExendin-4 as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: Exendin 4

Andere Bezeichnung: Exendin-4

Hintergrund: Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53% sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes ß-cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA squence encoding the 39 amino acid of Exendin-4. Synonym: Exendin-4. Formulation: Lyophilized from a 0.2um filtered solution of 20mM PBS, pH 7.0, containing 4% mannitol.

Molekulargewicht: Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.