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CXCL16 Protein

CXCL16-Protein exprimiert in Escherichia coli (E. coli).
Produktnummer ABIN987799

Kurzübersicht für CXCL16 Protein (ABIN987799)

Target

Alle CXCL16 Proteine anzeigen
CXCL16 (Chemokine (C-X-C Motif) Ligand 16 (CXCL16))

Biologische Aktivität

Active

Spezies

  • 10
  • 9
  • 2
  • 1
  • 1
  • 1
Maus

Quelle

  • 14
  • 3
  • 2
  • 2
  • 1
  • 1
Escherichia coli (E. coli)

Reinheit

> 98 % by SDS-PAGE and HPLC analyses.
  • Sequenz

    NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHL

    Produktmerkmale

    Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using murine lymphocytes is less than 1000 ng/ml, corresponding to a specific activity of >, 1.0 × 103 IU/mg.

    Endotoxin-Niveau

    Level Less than 1EU/µg of rMuCXCL16 as determined by LAL method
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

    Lagerung

    4 °C
  • Target

    CXCL16 (Chemokine (C-X-C Motif) Ligand 16 (CXCL16))

    Andere Bezeichnung

    CXCL16

    Hintergrund

    Mouse CXCL16 (CXC chemokine 16) is a nonELR motifcontaining CXC chemokine with a transmembrane domain. CX3CL1/Fractalkine and CXCL16 are the only two transmembrane chemokines within the superfamily. Mouse CXCL16 cDNA encodes a 246 amino acid (aa) precursor protein with a putative 26 aa residue signal peptide,an 88 aa residue chemokine domain, an 87 aa residue mucinlike spacer region, a 22 aa residue transmembrane domain, and a 23 aa residue cytoplasmic tail. Mouse and human CXCL16 share 49% overall aa identity and 70% similarity in the chemokine domains. Mouse CXCL16 is produced by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membranebound and soluble forms. Based on northern blot analysis,CXCL16 is also expressed in some nonlymphoid tissues such as lung, small intestine and kidney. The receptor for CXCL16 has been identified as CXCR6/Bonzo (STRL33 and TYMSTR), a receptor previously shown to be a coreceptor for HIV entry.CXCR6 is expressed on naive CD8 cells, naturalkiller T cells and activated CD8 and CD4 T cells. Synonym: CXCL16, Mouse. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS.

    Molekulargewicht

    Recombinant murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.
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